QuickView for COMP (gene)
- Gene Symbol:
- COMP
Homo sapiens - Full name:
- cartilage oligomeric matrix protein
- Synonyms:
- EDM1, EPD1, MED, PSACH, THBS5, TSP5, cartilage oligomeric matrix protein, cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple), pseudoachondroplasia (epiphyseal dysplasia 1, multiple), thrombospondin-5
- Genomic Location:
- Chr 19: 18754583-18763114
- Description:
-
The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appea...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Bos taurus , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Danio rerio
- External Links:
- Entrez Gene
- Cytogenetic Map:
-
19p13.11
GO Molecular Function
structural molecule activity | proteoglycan binding | cation binding | enzyme binding | protein-containing complex binding | lipid binding | vitamin binding | carbohydrate derivative binding | anion binding | collagen binding | vitamin D binding | ion binding | organic cyclic compound binding | heparin binding | heparan sulfate proteoglycan binding | protein binding | glycosaminoglycan binding | calcium ion binding | protease binding | steroid binding | metal ion binding | extracellular matrix structural constituent | fibronectin binding | small molecule binding
GO Biological Process
limb development | extracellular structure organization | regulation of programmed cell death | negative regulation of cellular process | bone development | organ growth | endochondral bone morphogenesis | cellular process | developmental growth | negative regulation of apoptotic process | growth plate cartilage development | tissue development | regulation of cellular process | regulation of apoptotic process | cellular component organization | programmed cell death | cartilage development involved in endochondral bone morphogenesis | extracellular matrix organization | cartilage development | apoptotic process | system development | multicellular organism development | animal organ morphogenesis | bone growth | skeletal system morphogenesis | bone morphogenesis | anatomical structure development | negative regulation of programmed cell death | cell adhesion | connective tissue development | cell death | animal organ development | anatomical structure morphogenesis | developmental process | skeletal system development | regulation of cell death | negative regulation of cell death | endochondral bone growth | multicellular organismal process
GO Cellular Component
extracellular matrix | collagen-containing extracellular matrix | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space
