QuickView for CTPS2 (gene)

Gene Symbol:

CTPS2 Homo sapiens

Full name:

CTP synthase 2

Synonyms:

CTP synthase 2, CTP synthase II, CTP synthetase type 2, UTP-ammonia ligase 2, cytidine 5'-triphosphate synthetase 2

Genomic Location:

Chr X: 16516043-16640980

Description:

The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Can...

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The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AREB6_02 ,  E2F1_Q4 ,  CAGGTG_E12_Q6 ,  MGGAAGTG_GABP_B ,  SCGGAAGY_ELK1_02

Cytogenetic Map:

Xp22.2

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