QuickView for Calcineurin A1 (gene)
- Gene Symbol:
- PPP3CB
Homo sapiens - Full name:
- protein phosphatase 3 catalytic subunit beta
- Synonyms:
- CALNA2, CALNB, CNA2, PP2Bbeta, serine/threonine-protein phosphatase 2B catalytic subunit beta isoform, CAM-PRP catalytic subunit, calcineurin A beta, calcineurin A2, calmodulin-dependent calcineurin A subunit beta isoform, protein phosphatase 2B, catalytic subunit, beta isoform, protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform, protein phosphatase 3, catalytic subunit, beta isozyme, protein phosphatase from PCR fragment H32
- Genomic Location:
- Chr 10: 74866618-74925758
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Saccharomyces cerevisiae , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-139 , Predicted Gene Targets for miR-15 , Predicted Gene Targets for miR-208 , Predicted Gene Targets for miR-26 , Predicted Gene Targets for miR-30 , Predicted Gene Targets for miR-324-3p , Predicted Gene Targets for miR-326 , Predicted Gene Targets for miR-137 , Predicted Gene Targets for miR-486 , Predicted Gene Targets for miR-493-5p
- Cytogenetic Map:
-
10q22.2
| Transcripts Names |
|---|
| NM_021132 |
| NM_001142353 |
| NM_001142354 |
| NM_001289969 |
| NM_001289968 |
| XM_017016379 |
| XM_005269944 |
GO Molecular Function
protein serine/threonine phosphatase activity | cation binding | enzyme binding | phosphatase activity | hydrolase activity | catalytic activity | phosphoprotein phosphatase activity | hydrolase activity, acting on ester bonds | ion binding | protein binding | protein phosphatase binding | protein phosphatase 2B binding | protein dimerization activity | phosphoric ester hydrolase activity | calcium ion binding | drug binding | calmodulin-dependent protein phosphatase activity | calmodulin binding | phosphatase binding | metal ion binding | calcium-dependent protein serine/threonine phosphatase activity
GO Biological Process
protein serine/threonine phosphatase activity | leukocyte homeostasis | regulation of T cell mediated immunity | positive regulation of insulin secretion involved in cellular response to glucose stimulus | cell morphogenesis | positive regulation of macromolecule biosynthetic process | negative regulation of immune system process | exocytosis | protein dephosphorylation | response to cytokine | neuron projection morphogenesis | immune response-regulating signaling pathway | regulation of cellular localization | intracellular signal transduction | regulation of localization | establishment of localization | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | social behavior | cell differentiation | regulation of T cell mediated cytotoxicity | nervous system development | response to drug | inositol phosphate-mediated signaling | cell part morphogenesis | regulation of leukocyte mediated cytotoxicity | neurogenesis | regulation of peptide hormone secretion | negative regulation of T cell mediated cytotoxicity | generation of neurons | positive regulation of protein secretion | neuron projection extension | positive regulation of cellular biosynthetic process | cellular process | secretion | lymphocyte differentiation | localization | cell projection morphogenesis | developmental growth | neuron development | immune system development | learning | positive regulation of nitrogen compound metabolic process | lymphangiogenesis | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of metabolic process | cellular component organization | T cell activation | phosphatase activity | lymph vessel morphogenesis | regulation of peptide secretion | response to stimulus | vasculature development | cell morphogenesis involved in neuron differentiation | regulation of insulin secretion | mononuclear cell proliferation | locomotion involved in locomotory behavior | secretion by cell | cardiovascular system development | positive regulation of hormone secretion | regulation of protein transport | positive regulation of RNA biosynthetic process | hemopoiesis | protein modification process | regulation of peptide transport | modulation of chemical synaptic transmission | macromolecule modification | cell-cell signaling | cell surface receptor signaling pathway involved in cell-cell signaling | negative regulation of adaptive immune response | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | leukocyte differentiation | locomotion | system development | nitrogen compound metabolic process | Wnt signaling pathway | multicellular organism development | phosphorus metabolic process | learning or memory | regulation of insulin secretion involved in cellular response to glucose stimulus | lymph vessel development | regulation of hormone levels | regulation of hormone secretion | regulation of gene expression | axon development | positive regulation of secretion | nervous system process | positive regulation of cellular metabolic process | phosphoprotein phosphatase activity | regulation of nitrogen compound metabolic process | vesicle-mediated transport | regulation of transcription by RNA polymerase II | axonogenesis | Fc-epsilon receptor signaling pathway | second-messenger-mediated signaling | cognition | non-canonical Wnt signaling pathway | homeostasis of number of cells | cell proliferation | leukocyte proliferation | locomotory behavior | negative regulation of immune response | phosphorylation | regulated exocytosis | protein phosphorylation | cell morphogenesis involved in differentiation | phosphate-containing compound metabolic process | cellular response to drug | cell communication | regulation of cellular metabolic process | lymphocyte homeostasis | heart development | homeostatic process | positive regulation of establishment of protein localization | regulation of RNA metabolic process | positive regulation of transport | positive regulation of peptide hormone secretion | lymphocyte activation | calcium-mediated signaling | neuron differentiation | T cell differentiation | Wnt signaling pathway, calcium modulating pathway | protein metabolic process | regulation of establishment of protein localization | response to organic substance | positive regulation of insulin secretion | axon extension | anatomical structure development | developmental growth involved in morphogenesis | cell surface receptor signaling pathway | cell projection organization | metabolic process | regulation of adaptive immune response | regulation of RNA biosynthetic process | calcium ion regulated exocytosis | regulation of secretion | behavior | neuron projection development | organic substance metabolic process | animal organ development | T cell proliferation | regulation of protein secretion | calcineurin-mediated signaling | calcineurin-NFAT signaling cascade | negative regulation of T cell mediated immunity | T cell homeostasis | cell activation | positive regulation of protein transport | anatomical structure formation involved in morphogenesis | memory | lymphocyte proliferation | regulation of cell communication | dephosphorylation | signaling | regulation of transcription, DNA-templated | cell development | cellular protein metabolic process | anatomical structure morphogenesis | developmental process | Fc receptor signaling pathway | calmodulin-dependent protein phosphatase activity | cellular protein modification process | regulation of transport | positive regulation of transcription, DNA-templated | developmental cell growth | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | positive regulation of metabolic process | regulation of synaptic plasticity | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | regulation of protein localization | calcium-dependent protein serine/threonine phosphatase activity | circulatory system development | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
supramolecular fiber | intracellular membrane-bounded organelle | sarcolemma | catalytic complex | sarcomere | cell | nuclear lumen | myofibril | cytoplasm | intracellular organelle | contractile fiber | protein-containing complex | nucleoplasm | plasma membrane | T-tubule | protein serine/threonine phosphatase complex | membrane-bounded organelle | nucleus | organelle | I band | calcineurin complex | cell periphery | membrane-enclosed lumen | Z disc | cytosol | intracellular | membrane | supramolecular complex
