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QuickView for Ceforanide (compound)
PubChem
| Name: | ceforanide |
|---|---|
| PubChem Compound ID: | 43507 |
| Molecular formula: | C20H21N7O6S2 |
| Molecular weight: | 519.556 g/mol |
| Synonyms: |
Ceforanide; Prestwick1_000470; Prestwick0_000470; AIDS-007642; Ceforanide (USP); (6R-trans)-7-(((2-(Aminomethyl)phenyl)acetyl)amino)-3-(((1-(carboxymethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid; AIDS007642; Ceforanido [INN-Spanish]; Ceforanidum [INN-Latin]; (6R,7R)-7-(2-(alpha-Amino-o-tolyl)acetamido)-3-(((1-(carboxymethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid.
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DrugBank
Identification
| Name: | ceforanide |
|---|---|
| Name (isomeric): | DB00923 |
| Drug Type: | small molecule |
| Synonyms: |
Ceforanido [INN-Spanish]; Ceforanidum [INN-Latin]
|
| Brand: | Precef |
| Category: | Cephalosporins, Anti-Bacterial Agents |
| CAS number: | 60925-61-3 |
Pharmacology
| Indication: | For the treatment of infections caused by susceptible organisms. |
|---|---|
| Pharmacology: | Ceforanide is a semisynthetic second-generation cephalosporin. The cephalosporins are bactericidal drugs with both gram-positive and gram-negative activity. They inhibit bacterial cell wall synthesis in a way similar to the penicillins. |
| Mechanism of Action: | The bactericidal activity of ceforanide results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). |
| Absorption: | Rapidly absorbed following intramuscular injection. |
| Protein binding: | 80.6% |
| Biotransformation: | The major drug elimination route was urinary excretion with 85% of the dose being excreted unchanged in the urine within 12 hr, and no metabolites with antibiotic activity were observed in urine. |
| Half Life: | 2.6 to 2.98 hours |
| Toxicity: | Adverse effects following overdosage include nausea, vomiting, epigastric distress, diarrhea, and convulsions. |
| Affected organisms: | Enteric bacteria and other eubacteria |
Interactions
| Drug interaction: |
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Targets
