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QuickView for Ceftizoxime (compound)
PubChem
| Name: | Ceftizoxime |
|---|---|
| PubChem Compound ID: | 2655 |
| Description: | A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders. |
| Molecular formula: | C13H13N5O5S2 |
| Molecular weight: | 383.405 g/mol |
DrugBank
Identification
| Name: | Ceftizoxime |
|---|---|
| Name (isomeric): | DB01332 |
| Drug Type: | small molecule |
| Description: | A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders. |
| Synonyms: |
Ceftizoximum [inn-latin]; Ceftizoxima [inn-spanish]
|
| Brand: | Cefizox in plastic container, Eposerin, Cefizox, Epocelin, Ceftix |
| Category: | Cephalosporins, Anti-Bacterial Agents |
| CAS number: | 68401-81-0 |
Pharmacology
| Indication: | For the treatment of infections due to susceptible strains of microorganisms. |
|---|---|
| Pharmacology: | Ceftizoxime is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders. |
| Mechanism of Action: |
Ceftizoxime is an aminothiazolyl cephalosporin with an extended spectrum of activity against many gram-negative, nosocomially acquired pathogens. It has excellent beta-lactamase stability, with good in vitro activity against Haemophilus influenzae, Neisseria gonorrhoeae and Klebsiella pneumoniae. Ceftizoxime, like the penicillins, is a beta-lactam ...
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| Protein binding: | 30% protein bound |
| Biotransformation: | Ceftizoxime is not metabolized, and is excreted virtually unchanged by the kidneys in 24 hours. |
| Route of elimination: | Ceftizoxime is not metabolized, and is excreted virtually unchanged by the kidneys in 24 hours. |
| Affected organisms: | Enteric bacteria and other eubacteria |
Interactions
| Drug interaction: |
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Targets
Transporters
