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QuickView for Doxapram (compound)
PubChem
| Name: | Doxapram |
|---|---|
| PubChem Compound ID: | 3156 |
| Description: | A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225) |
| Molecular formula: | C24H30N2O2 |
| Molecular weight: | 378.507 g/mol |
| Synonyms: |
Doxapramum [INN-Latin]; Dopram; 2-Pyrrolidinone, 1-ethyl-4-(2-(4-morpholinyl)ethyl)-3,3-diphenyl- (9CI); 2-Pyrrolidinone, 1-ethyl-4-(2-(4-morpholinyl)ethyl)-3,3-diphenyl-; BRN 0628691; NSC170958; Stimulexin; 2-Pyrrolidinone, 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-; 113-07-5; EINECS 206-216-3.
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DrugBank
Identification
| Name: | Doxapram |
|---|---|
| Name (isomeric): | DB00561 |
| Drug Type: | small molecule |
| Description: | A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225) |
| Brand: | Doxapram HCL, Stimulexin, Dopram, Doxapram hydrochloride |
| Category: | Respiratory System Agents, Central Nervous System Stimulants |
| CAS number: | 309-29-5 |
Pharmacology
| Indication: | For use as a temporary measure in hospitalized patients with acute respiratory insufficiency superimposed on chronic obstructive pulmonary disease. |
|---|---|
| Pharmacology: |
Doxapram is an analeptic agent (a stimulant of the central nervous system). The respiratory stimulant action is manifested by an increase in tidal volume associated with a slight increase in respiratory rate. A pressor response may result following doxapram administration. Provided there is no impairment of cardiac function, the pressor effect is m...
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| Mechanism of Action: | Doxapram produces respiratory stimulation mediated through the peripheral carotid chemoreceptors. It is thought to stimulate the carotid body by inhibiting certain potassium channels. |
| Toxicity: | Intravenous LD50 values in the mouse and rat were approximately 75 mg/kg and in the cat and dog were 40 to 80 mg/kg. Symptoms of overdosage are extensions of the pharmacologic effects of the drug. Excessive pressor effect, tachycardia, skeletal muscle hyperactivity, and enhanced deep tendon reflexes may be early signs of overdosage. |
| Affected organisms: | Humans and other mammals |
Targets
