Name: | dutasteride |
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PubChem Compound ID: | 152945 |
Molecular formula: | C27H30F6N2O2 |
Molecular weight: | 528.53 g/mol |
Synonyms: |
GI 198745; Avodart; GG 745; 164656-23-9; Dutasteride; Dutasteride [USAN]; (5alpha,17beta)-N-(2,5-Bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide; alpha,alpha,alpha,alpha',alpha',alpha'-Hexafluoro-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxy-2',5'-xylidide
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Name: | dutasteride |
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Name (isomeric): | DB01126 |
Drug Type: | small molecule |
Brand: | Avodart |
Category: | Anti-baldness Agents, Antihyperplasia Agents, Enzyme Inhibitors |
CAS number: | 164656-23-9 |
Indication: | For the treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate gland to improve symptoms, and reduce the risk of acute urinary retention and the need for surgery. |
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Pharmacology: |
Dutasteride is a synthetic 4-azasteroid compound that is a selective inhibitor of both the type 1 and type 2 isoforms of steroid 5 alpha-reductase (5AR), intracellular enzymes that convert testosterone to 5 alpha-dihydrotestosterone (DHT). Type I 5a-reductase is predominant in the sebaceous glands of most regions of skin, including scalp, and liver...
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Mechanism of Action: |
Dutasteride inhibits the conversion of testosterone to 5 alpha-dihydrotestosterone (DHT), which is the androgen primarily responsible for the initial development and subsequent enlargement of the prostate gland. Testosterone is converted to DHT by the enzyme 5 alpha-reductase, which exists as 2 isoforms, type 1 and type 2. Dutasteride is a competit...
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Absorption: | 60% |
Protein binding: | Highly bound to albumin (99%) and α-1 acid glycoprotein (96.6%). |
Biotransformation: | Hepatic. Extensively metabolized by CYP3A4 and CYP3A5 to active metabolites. |
Route of elimination: | Dutasteride is extensively metabolized in humans. Dutasteride and its metabolites were excreted mainly in feces. |
Half Life: | 5 weeks |
Affected organisms: | Humans and other mammals |
Food interaction: |
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