QuickView for EPC1;jsessionid=05B727736D356F050818467779AB0578 (gene)
- Gene Symbol:
- EPC1
Homo sapiens - Full name:
- enhancer of polycomb homolog 1
- Synonyms:
- Epl1, enhancer of polycomb homolog 1
- Genomic Location:
- Chr 10: 32597865-32676119
- Description:
-
This gene encodes a member of the polycomb group (PcG) family. The encoded protein is a component of the NuA4 histone acetyltransferase complex and can act as both a transcriptional activator and repressor. The encoded protein has been linked to apoptosis, DNA repair, skeletal muscle differentiation, gene silencing, and adult T-cell leukemia/lympho...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
10p11.22
| Transcripts Names |
|---|
| NM_025209 |
| NR_073538 |
| NM_001272004 |
| NM_001272019 |
| NR_104160 |
| XR_001747215 |
| NR_104159 |
| XR_001747214 |
| XM_006717510 |
| NM_001282391 |
GO Molecular Function
N-acetyltransferase activity | transferase activity, transferring acyl groups other than amino-acyl groups | N-acyltransferase activity | catalytic activity | transferase activity, transferring acyl groups | histone acetyltransferase activity | peptide N-acetyltransferase activity | protein binding | transferase activity | peptide-lysine-N-acetyltransferase activity | acetyltransferase activity
GO Biological Process
RNA metabolic process | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | peptidyl-amino acid modification | smooth muscle cell differentiation | negative regulation of cellular process | negative regulation of RNA biosynthetic process | histone modification | cell differentiation | positive regulation of cellular biosynthetic process | cellular process | regulation of gene expression, epigenetic | chromatin organization | negative regulation of nucleic acid-templated transcription | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | muscle structure development | muscle cell differentiation | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | histone H4 acetylation | vasculature development | cellular nitrogen compound biosynthetic process | vascular smooth muscle cell differentiation | cardiovascular system development | peptidyl-lysine acetylation | cellular nitrogen compound metabolic process | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | protein modification process | cellular biosynthetic process | macromolecule modification | regulation of nucleic acid-templated transcription | system development | nitrogen compound metabolic process | multicellular organism development | protein acetylation | histone acetyltransferase activity | regulation of gene expression | negative regulation of gene expression, epigenetic | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | negative regulation of G0 to G1 transition | histone acetylation | internal peptidyl-lysine acetylation | biosynthetic process | histone H2A acetylation | aromatic compound biosynthetic process | regulation of cellular metabolic process | regulation of RNA metabolic process | protein metabolic process | regulation of growth | anatomical structure development | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | peptidyl-lysine modification | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | regulation of G0 to G1 transition | transcription, DNA-templated | negative regulation of cell cycle | covalent chromatin modification | regulation of transcription, DNA-templated | internal protein amino acid acetylation | cellular protein metabolic process | cellular macromolecule biosynthetic process | developmental process | organelle organization | cellular protein modification process | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | chromosome organization | cellular metabolic process | negative regulation of cell cycle process | circulatory system development | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | catalytic complex | organelle membrane | nuclear membrane | cell | nuclear lumen | histone acetyltransferase complex | H4/H2A histone acetyltransferase complex | intracellular organelle | protein-containing complex | endomembrane system | nucleoplasm | nuclear envelope | transferase complex | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | protein acetyltransferase complex | Piccolo NuA4 histone acetyltransferase complex | intracellular | membrane | NuA4 histone acetyltransferase complex
