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QuickView for Estramustine (compound)
PubChem
| Name: | Estramustine |
|---|---|
| PubChem Compound ID: | 18140 |
| Description: | A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties. |
| Molecular formula: | C23H31Cl2NO3 |
| Molecular weight: | 440.403 g/mol |
| Synonyms: |
17.Beta.-Estradiol {3-[bis(2-chloroethyl)carbamate]}; Estradiol 3-(bis(2-chloroethyl)carbamate); Estra-1,3,5(10)-triene-3,17-diol (17.beta.)-, 3-[bis(2-chloroethyl)carbamate]; Estramustina [INN-Spanish]; Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 3-(bis(2-chloroethyl)carbamate) (9CI); Estramustinum [INN-Latin]; Emcyt; Estra-1,3,5(10)-triene-3,17-diol, 3-(bis(2-chloroethyl)carbamate), (17beta)-; Estracyt; EINECS 221-076-3.
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DrugBank
Identification
| Name: | Estramustine |
|---|---|
| Name (isomeric): | DB01196 |
| Drug Type: | small molecule |
| Description: | A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties. |
| Synonyms: |
Estramustina [INN-Spanish]; Estramustinum [INN-Latin]; Estramustine Sodium Phosphate; Estramustin Sodium Phosphate
|
| Brand: | Estracyt, Emcyt |
| Category: | Radiation-Protective Agents, Antineoplastic Agents, Hormonal, Antineoplastic Agents, Antineoplastic Agents, Alkylating |
| CAS number: | 2998-57-4 |
Pharmacology
| Indication: | For the palliative treatment of patients with metastatic and/or progressive carcinoma of the prostate |
|---|---|
| Pharmacology: |
Estramustine is an antineoplastic agent indicated in the palliative treatment of patients with metastatic and/or progressive carcinoma of the prostate. Estramustine is a combination of estradiol with nitrogen mustard. In vivo, the nitrogen-mustard moiety becomes active and participates in alkylation of DNA or other cellular components.. This causes...
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| Mechanism of Action: |
Estramustine is a derivative of estradiol with a nitrogen mustard moiety. This gives it alkylating properties. In vivo, the nitrogen mustard component is active and can alklyate DNA and other cellular components (such as tubulin components) of rapidly dividing cells. This causes DNA strandbreaks or misscoding events. This leads to apoptosis and cel...
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| Route of elimination: | The metabolic urinary patterns of the estradiol moiety of estramustine phosphate and estradiol itself are very similar, although the metabolites derived from estramustine phosphate are excreted at a slower rate. |
| Half Life: | 20 hours |
| Affected organisms: | Humans and other mammals |
Interactions
| Food interaction: |
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Targets
Enzymes
Transporters
