QuickView for FAR1 (gene)

Gene Symbol:

FAR1 Homo sapiens

Full name:

fatty acyl-CoA reductase 1

Synonyms:

MLSTD2, PFCRD, SDR10E1, fatty acyl-CoA reductase 1, male sterility domain-containing protein 2, short chain dehydrogenase/reductase family 10E, member 1

Genomic Location:

Chr 11: 13646847-13710469

Description:

The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, an...

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The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGTG_MIR128A_MIR128B ,  GTAAACC_MIR2995P ,  TAGCTTT_MIR9 ,  AGCATTA_MIR155 ,  CEBPB_01 ,  GGGYGTGNY_UNKNOWN ,  ALPHACP1_01 ,  TGCCTTA_MIR124A ,  ATTCTTT_MIR186 ,  GTGCCTT_MIR506 ,  TTGTTT_FOXO4_01 ,  WTTGKCTG_UNKNOWN ,  CCAATNNSNNNGCG_UNKNOWN

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-143 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-299 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-155 ,  Predicted Gene Targets for miR-496 ,  Predicted Gene Targets for miR-505

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Cytogenetic Map:

11p15.3

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