QuickView for FOLR2 (gene)

Gene Symbol:

FOLR2 Homo sapiens

Full name:

folate receptor beta

Synonyms:

BETA-HFR, FBP, FBP/PL-1, FR-BETA, FR-P3, folate receptor beta, folate receptor 2 (fetal), folate receptor, fetal/placental, folate-binding protein, fetal/placental, placental folate-binding protein

Genomic Location:

Chr 11: 71605488-71610637

Description:

The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68%...

View Full Description

The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

YATTNATC_UNKNOWN ,  GGGTGGRR_PAX4_03

Cytogenetic Map:

11q13.4

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