QuickView for FTL;jsessionid=B32E8298E8BC407BE4E8D24FFB10101E (gene)

Gene Symbol:

FTL Homo sapiens

Full name:

ferritin light chain

Synonyms:

LFTD, NBIA3, ferritin light chain, ferritin L subunit, ferritin L-chain, ferritin light polypeptide-like 3, ferritin, light polypeptide

Genomic Location:

Chr 19: 54160378-54161948

Description:

This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of...

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This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Canis lupus familiaris ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CAGCTTT_MIR320 ,  GGCAGCT_MIR22 ,  CTTTGT_LEF1_Q2

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-320

Cytogenetic Map:

19q13.33

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