QuickView for GCAT;jsessionid=D33A7D86980C7A8EF5C5E02A0F4C70B5 (gene)

Gene Symbol:

GCAT Homo sapiens

Full name:

glycine C-acetyltransferase

Synonyms:

KBL, 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial, 2-amino-3-ketobutyrate-CoA ligase, AKB ligase, aminoacetone synthase, glycine acetyltransferase

Genomic Location:

Chr 22: 36533901-36542850

Description:

The degradation of L-threonine to glycine consists of a two-step biochemical pathway involving the enzymes L-threonine dehydrogenase and 2-amino-3-ketobutyrate coenzyme A ligase. L-Threonine is first converted into 2-amino-3-ketobutyrate by L-threonine dehydrogenase. This gene encodes the second enzyme in this pathway, which then catalyzes the reac...

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The degradation of L-threonine to glycine consists of a two-step biochemical pathway involving the enzymes L-threonine dehydrogenase and 2-amino-3-ketobutyrate coenzyme A ligase. L-Threonine is first converted into 2-amino-3-ketobutyrate by L-threonine dehydrogenase. This gene encodes the second enzyme in this pathway, which then catalyzes the reaction between 2-amino-3-ketobutyrate and coenzyme A to form glycine and acetyl-CoA. The encoded enzyme is considered a class II pyridoxal-phosphate-dependent aminotransferase. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 14.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  TGIF_01 ,  YTATTTTNR_MEF2_02 ,  TTF1_Q6 ,  E2A_Q2 ,  NFE2_01 ,  TITF1_Q3 ,  CTTTAAR_UNKNOWN ,  MEIS1_01 ,  MYB_Q6 ,  TTGTTT_FOXO4_01 ,  TGACAGNY_MEIS1_01 ,  CAGCTG_AP4_Q5 ,  MMEF2_Q6 ,  AACTTT_UNKNOWN ,  MYB_Q3

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Cytogenetic Map:

22q13.1

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