QuickView for GPX2 (gene)

Gene Symbol:

GPX2 Homo sapiens

Full name:

glutathione peroxidase 2

Synonyms:

GI-GPx, GPRP, GPRP-2, GPx-2, GPx-GI, GSHPX-GI, GSHPx-2, glutathione peroxidase 2, gastrointestinal glutathione peroxidase, glutathione peroxidase 2 (gastrointestinal), glutathione peroxidase-related protein 2

Genomic Location:

Chr 14: 64475625-64479284

Description:

The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate spe...

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The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human), is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TFIIA_Q6 ,  CTTTGA_LEF1_Q2 ,  TCF4_Q5 ,  GGGAGGRR_MAZ_Q6 ,  CAGGTG_E12_Q6 ,  HNF4_Q6 ,  NRF2_Q4 ,  TGATTTRY_GFI1_01 ,  GGGTGGRR_PAX4_03 ,  CCTNTMAGA_UNKNOWN ,  TCF11MAFG_01

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Cytogenetic Map:

14q23.3

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