QuickView for GRG5 (gene)
- Gene Symbol:
- AES
Homo sapiens - Full name:
- amino-terminal enhancer of split
- Synonyms:
- AES-1, AES-2, ESP1, GRG, GRG5, Grg-5, TLE5, amino-terminal enhancer of split, gp130-associated protein GAM, groucho-related protein 5
- Genomic Location:
- Chr 19: 3003908-3013964
- Description:
-
The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantl...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Canis lupus familiaris , Bos taurus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
19p13.3
GO Molecular Function
repressing transcription factor binding | transcription corepressor activity | protein binding | transcription factor binding | transcription coregulator activity
GO Biological Process
RNA metabolic process | response to extracellular stimulus | response to cytokine | response to interleukin-1 | positive regulation of apoptotic process | regulation of programmed cell death | negative regulation of cellular process | negative regulation of RNA biosynthetic process | cellular response to extracellular stimulus | cellular process | negative regulation of signaling | negative regulation of nucleic acid-templated transcription | regulation of response to cytokine stimulus | regulation of canonical Wnt signaling pathway | negative regulation of cellular metabolic process | regulation of binding | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | response to stimulus | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | negative regulation of metabolic process | regulation of anoikis | cellular biosynthetic process | cell-cell signaling | cell surface receptor signaling pathway involved in cell-cell signaling | regulation of nucleic acid-templated transcription | system development | nitrogen compound metabolic process | regulation of signal transduction | Wnt signaling pathway | multicellular organism development | regulation of gene expression | animal organ morphogenesis | regulation of nitrogen compound metabolic process | transcription corepressor activity | regulation of transcription by RNA polymerase II | negative regulation of binding | biosynthetic process | aromatic compound biosynthetic process | cell communication | negative regulation of protein binding | regulation of cellular metabolic process | regulation of RNA metabolic process | regulation of growth | response to organic substance | anatomical structure development | cell surface receptor signaling pathway | negative regulation of response to cytokine stimulus | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | positive regulation of cell death | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | gene expression | positive regulation of programmed cell death | regulation of Wnt signaling pathway | transcription, DNA-templated | regulation of cell communication | positive regulation of anoikis | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | regulation of protein binding | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | developmental process | negative regulation of canonical Wnt signaling pathway | negative regulation of transcription by RNA polymerase II | transcription coregulator activity | heterocycle metabolic process | negative regulation of Wnt signaling pathway | skeletal system development | cellular metabolic process | regulation of cell death | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | cell | transcription factor complex | intracellular organelle | protein-containing complex | membrane-bounded organelle | nucleus | organelle | intracellular
