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QuickView for GRIA1 (gene)


Gene Symbol:
GRIA1 Homo sapiens Homo sapiens
Full name:
glutamate ionotropic receptor AMPA type subunit 1
Synonyms:
GLUH1, GLUR1, GLURA, GluA1, HBGR1, glutamate receptor 1, AMPA 1, AMPA-selective glutamate receptor 1, gluR-1, gluR-A, gluR-K1, glutamate receptor, ionotropic, AMPA 1
Genomic Location:
Chr 5: 152850499-153171354
Description:
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classifica...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 5
5q33.2





GO Molecular Function

transmitter-gated ion channel activity | neurotransmitter receptor activity | peptide binding | amyloid-beta binding | passive transmembrane transporter activity | transmembrane signaling receptor activity | transmembrane transporter activity | ligand-gated ion channel activity | ion gated channel activity | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | protein domain specific binding | cation transmembrane transporter activity | amide binding | signaling receptor activity | transporter activity | ion transmembrane transporter activity | AMPA glutamate receptor activity | extracellular ligand-gated ion channel activity | glutamate receptor activity | protein binding | ionotropic glutamate receptor activity | neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration | excitatory extracellular ligand-gated ion channel activity | cation channel activity | inorganic cation transmembrane transporter activity | PDZ domain binding | channel activity | ion channel activity | substrate-specific channel activity

GO Biological Process

transmitter-gated ion channel activity | long-term memory | establishment of localization | negative regulation of cellular process | excitatory postsynaptic potential | cellular chemical homeostasis | membrane organization | intracellular transport | cellular process | establishment of organelle localization | localization | cellular homeostasis | passive transmembrane transporter activity | negative regulation of signaling | chemical synaptic transmission | establishment of localization in cell | vesicle targeting, to, from or within Golgi | regulation of cellular process | regulation of cytosolic calcium ion concentration | organelle localization | transmembrane transporter activity | ligand-gated ion channel activity | cellular component organization | calcium ion homeostasis | response to stimulus | ion gated channel activity | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | COPII-coated vesicle budding | cellular localization | cellular component assembly | modulation of chemical synaptic transmission | vesicle targeting | cell-cell signaling | cell surface receptor signaling pathway involved in cell-cell signaling | metal ion homeostasis | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | regulation of membrane potential | learning or memory | ion transmembrane transport | regulation of postsynaptic membrane potential | vesicle coating | nervous system process | synaptic signaling | cation transmembrane transporter activity | cellular ion homeostasis | vesicle-mediated transport | ion transmembrane transporter activity | Golgi vesicle budding | cognition | AMPA glutamate receptor activity | establishment of vesicle localization | extracellular ligand-gated ion channel activity | cation homeostasis | cellular cation homeostasis | cell communication | receptor internalization | cellular calcium ion homeostasis | homeostatic process | Golgi vesicle transport | long term synaptic depression | cation transmembrane transport | protein-containing complex assembly | ionotropic glutamate receptor activity | import into cell | cell surface receptor signaling pathway | neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration | metabolic process | regulation of postsynaptic cytosolic calcium ion concentration | chemical homeostasis | endocytosis | behavior | organic substance metabolic process | excitatory extracellular ligand-gated ion channel activity | ion homeostasis | vesicle organization | vesicle budding from membrane | cation channel activity | memory | regulation of cell communication | ER to Golgi vesicle-mediated transport | transmembrane transport | signaling | inorganic cation transmembrane transporter activity | cation transport | channel activity | glutamate receptor signaling pathway | receptor-mediated endocytosis | organelle organization | COPII vesicle coating | receptor metabolic process | cellular metal ion homeostasis | negative regulation of synaptic transmission | ion channel activity | regulation of synaptic plasticity | vesicle localization | ion transport | cellular metabolic process | ionotropic glutamate receptor signaling pathway | divalent inorganic cation homeostasis | substrate-specific channel activity | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

endoplasmic reticulum-Golgi intermediate compartment | dendritic spine | exocytic vesicle | integral component of membrane | dendrite | intracellular membrane-bounded organelle | early endosome membrane | synapse | ER to Golgi transport vesicle membrane | neuron projection | endocytic vesicle membrane | somatodendritic compartment | dendritic spine membrane | organelle membrane | cell projection membrane | postsynaptic specialization membrane | cytoplasmic vesicle | Golgi-associated vesicle membrane | cell body | cell | neuronal cell body | plasma membrane protein complex | COPII-coated ER to Golgi transport vesicle | intrinsic component of membrane | synaptic membrane | axonal spine | transport vesicle membrane | cytoplasm | intracellular organelle | receptor complex | endoplasmic reticulum | dendritic tree | leading edge membrane | presynapse | endosome membrane | Golgi apparatus | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | endoplasmic reticulum-Golgi intermediate compartment membrane | cell projection | recycling endosome | secretory vesicle | postsynaptic membrane | endomembrane system | neuron spine | endoplasmic reticulum membrane | postsynapse | plasma membrane | Golgi-associated vesicle | cell leading edge | postsynaptic density membrane | vesicle | transport vesicle | postsynaptic density | asymmetric synapse | integral component of plasma membrane | synaptic vesicle | Golgi membrane | endosome | coated vesicle membrane | dendrite membrane | membrane-bounded organelle | organelle | recycling endosome membrane | postsynaptic specialization | vesicle membrane | cell periphery | axon | early endosome | ionotropic glutamate receptor complex | transmembrane transporter complex | cation channel complex | ion channel complex | intracellular vesicle | cell surface | endocytic vesicle | intracellular | cell junction | membrane | cytoplasmic vesicle membrane | neuron projection membrane | AMPA glutamate receptor complex | intrinsic component of plasma membrane | coated vesicle