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QuickView for GRIK5;jsessionid=CCECCECB550BB2F9A61668FC6CE8BDB9 (gene)


Gene Symbol:
GRIK5 Homo sapiens Homo sapiens
Full name:
glutamate ionotropic receptor kainate type subunit 5
Synonyms:
EAA2, GRIK2, GluK5, KA2, glutamate receptor ionotropic, kainate 5, excitatory amino acid receptor 2, glutamate receptor KA2
Genomic Location:
Chr 19: 47194313-47261797
Description:
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring io...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 19
19q13.2





GO Molecular Function

transmitter-gated ion channel activity | neurotransmitter receptor activity | passive transmembrane transporter activity | transmembrane signaling receptor activity | transmembrane transporter activity | SH3 domain binding | ligand-gated ion channel activity | ion gated channel activity | protein domain specific binding | kainate selective glutamate receptor activity | cation transmembrane transporter activity | signaling receptor activity | transporter activity | identical protein binding | ion transmembrane transporter activity | extracellular ligand-gated ion channel activity | glutamate receptor activity | protein binding | potassium channel activity | ionotropic glutamate receptor activity | metal ion transmembrane transporter activity | potassium ion transmembrane transporter activity | sodium ion transmembrane transporter activity | sodium channel activity | cation channel activity | inorganic cation transmembrane transporter activity | monovalent inorganic cation transmembrane transporter activity | PDZ domain binding | channel activity | ion channel activity | substrate-specific channel activity

GO Biological Process

transmitter-gated ion channel activity | cellular response to glucose stimulus | regulation of cellular localization | positive regulation of apoptotic process | regulation of localization | regulation of programmed cell death | establishment of localization | excitatory postsynaptic potential | cellular chemical homeostasis | glucose homeostasis | regulation of organelle organization | regulation of neuron death | cellular process | localization | cellular homeostasis | passive transmembrane transporter activity | metal ion transport | chemical synaptic transmission | protein localization to endoplasmic reticulum | macromolecule localization | establishment of localization in cell | regulation of cellular process | regulation of apoptotic process | transmembrane transporter activity | ligand-gated ion channel activity | response to stimulus | ion gated channel activity | response to glucose | receptor clustering | cellular localization | maintenance of protein localization in organelle | modulation of chemical synaptic transmission | cell-cell signaling | regulation of intracellular transport | cell surface receptor signaling pathway involved in cell-cell signaling | regulation of membrane potential | regulation of neurotransmitter levels | cellular glucose homeostasis | regulation of synaptic vesicle exocytosis | ion transmembrane transport | localization within membrane | regulation of postsynaptic membrane potential | protein localization to membrane | nervous system process | synaptic signaling | kainate selective glutamate receptor activity | sodium ion transport | cation transmembrane transporter activity | monovalent inorganic cation transport | cellular potassium ion transport | ion transmembrane transporter activity | potassium ion transport | protein localization to organelle | synaptic transmission, glutamatergic | extracellular ligand-gated ion channel activity | protein retention in ER lumen | positive regulation of neuron death | regulation of synaptic vesicle transport | maintenance of protein location | cell communication | regulation of neuron apoptotic process | homeostatic process | response to monosaccharide | regulation of vesicle fusion | cation transmembrane transport | potassium channel activity | regulation of synaptic vesicle fusion to presynaptic active zone membrane | response to organic substance | ionotropic glutamate receptor activity | metal ion transmembrane transporter activity | regulation of exocytosis | positive regulation of neuron apoptotic process | cell surface receptor signaling pathway | potassium ion transmembrane transporter activity | cellular protein localization | cellular response to carbohydrate stimulus | regulation of vesicle-mediated transport | chemical homeostasis | regulation of secretion | positive regulation of cell death | sodium ion transmembrane transport | maintenance of protein localization in endoplasmic reticulum | positive regulation of programmed cell death | sodium ion transmembrane transporter activity | maintenance of protein location in cell | inorganic cation transmembrane transport | sodium channel activity | regulation of regulated secretory pathway | cation channel activity | regulation of cell communication | transmembrane transport | signaling | inorganic cation transmembrane transporter activity | monovalent inorganic cation transmembrane transporter activity | protein localization | cation transport | cellular macromolecule localization | channel activity | glutamate receptor signaling pathway | regulation of transport | potassium ion transmembrane transport | regulation of calcium ion-dependent exocytosis | ion channel activity | ion transport | cellular response to organic substance | regulation of cell death | response to carbohydrate | ionotropic glutamate receptor signaling pathway | carbohydrate homeostasis | substrate-specific channel activity | regulation of cellular component organization | signal transduction | regulation of signaling | regulation of neurotransmitter secretion | maintenance of location in cell | multicellular organismal process

GO Cellular Component

presynaptic membrane | integral component of membrane | dendrite | intracellular membrane-bounded organelle | synapse | neuron projection | potassium channel complex | somatodendritic compartment | cell body | cell | neuronal cell body | plasma membrane protein complex | distal axon | intrinsic component of membrane | synaptic membrane | terminal bouton | cytoplasm | intracellular organelle | receptor complex | endoplasmic reticulum | dendritic tree | presynapse | protein-containing complex | cell projection | postsynaptic membrane | endomembrane system | postsynapse | plasma membrane | perikaryon | kainate selective glutamate receptor complex | postsynaptic density | asymmetric synapse | integral component of plasma membrane | membrane-bounded organelle | nucleus | organelle | postsynaptic specialization | axon terminus | sodium channel complex | cell periphery | axon | ionotropic glutamate receptor complex | transmembrane transporter complex | neuron projection terminus | cation channel complex | ion channel complex | intracellular | cell junction | membrane | intrinsic component of plasma membrane