QuickView for GRK5 (gene)
- Gene Symbol:
- GRK5
Homo sapiens - Full name:
- G protein-coupled receptor kinase 5
- Synonyms:
- GPRK5, G protein-coupled receptor kinase 5, FP2025, g protein-coupled receptor kinase GRK5
- Genomic Location:
- Chr 10: 120957187-121205121
- Description:
-
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonucle...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Bos taurus , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
10q26.11
GO Molecular Function
kinase binding | protein kinase binding | enzyme binding | ribonucleotide binding | lipid binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | phospholipid binding | catalytic activity | ATP binding | G-protein coupled receptor kinase activity | protein kinase C binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | beta-adrenergic receptor kinase activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | heterocyclic compound binding | small molecule binding
GO Biological Process
regulation of programmed cell death | negative regulation of cellular process | cell differentiation | cellular process | negative regulation of apoptotic process | regulation of cell cycle | regulation of cellular process | regulation of apoptotic process | response to stimulus | regulation of cell proliferation | protein serine/threonine kinase activity | programmed cell death | G-protein coupled receptor signaling pathway | protein modification process | macromolecule modification | cell-cell signaling | cell surface receptor signaling pathway involved in cell-cell signaling | apoptotic process | G-protein coupled receptor kinase activity | nitrogen compound metabolic process | regulation of signal transduction | Wnt signaling pathway | phosphorus metabolic process | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | tachykinin receptor signaling pathway | protein autophosphorylation | fat cell differentiation | phosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | positive regulation of cell proliferation | protein metabolic process | beta-adrenergic receptor kinase activity | cell surface receptor signaling pathway | metabolic process | negative regulation of programmed cell death | protein kinase activity | organic substance metabolic process | cell death | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | regulation of cell communication | signaling | cellular protein metabolic process | regulation of G-protein coupled receptor protein signaling pathway | kinase activity | developmental process | cellular protein modification process | cellular metabolic process | regulation of cell death | negative regulation of cell death | signal transduction | regulation of signaling | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | organelle membrane | nuclear membrane | cell | nuclear lumen | cytoplasm | intracellular organelle | nuclear body | endomembrane system | nucleoplasm | plasma membrane | nuclear envelope | nuclear speck | membrane-bounded organelle | nucleus | organelle | cell periphery | membrane-enclosed lumen | cytosol | intracellular | membrane
