QuickView for GSK3B;jsessionid=8D33F2A535E92EE112E8029E62EB490B (gene)
- Gene Symbol:
- GSK3B
Homo sapiens - Full name:
- glycogen synthase kinase 3 beta
- Synonyms:
- glycogen synthase kinase-3 beta, GSK-3 beta, GSK3beta isoform, serine/threonine-protein kinase GSK3B
- Genomic Location:
- Chr 3: 121028233-121295203
- Description:
-
The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Al...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
3q13.33
GO Molecular Function
beta-catenin binding | tau-protein kinase activity | kinase binding | NF-kappaB binding | protein kinase binding | enzyme binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | catalytic activity | ATP binding | ubiquitin-like protein ligase binding | cytoskeletal protein binding | protein kinase A catalytic subunit binding | anion binding | adenyl nucleotide binding | p53 binding | protein kinase A binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | transcription factor binding | dynactin binding | ubiquitin protein ligase binding | RNA polymerase II transcription factor binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | protease binding | heterocyclic compound binding | small molecule binding
GO Biological Process
tau-protein kinase activity | brain development | regulation of dephosphorylation | regulation of intracellular protein transport | response to endoplasmic reticulum stress | response to cytokine | positive regulation of cellular component organization | regulation of cell morphogenesis | regulation of neurogenesis | negative regulation of type B pancreatic cell development | regulation of cellular localization | neuron projection retraction | intracellular signal transduction | positive regulation of apoptotic process | regulation of cell development | regulation of localization | regulation of carbohydrate metabolic process | regulation of programmed cell death | peptidyl-amino acid modification | hippocampus development | establishment of localization | negative regulation of neuron death | negative regulation of cellular process | regulation of phosphatase activity | superior temporal gyrus development | cell differentiation | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | excitatory postsynaptic potential | nervous system development | epithelial to mesenchymal transition | positive regulation of protein catabolic process | generation of precursor metabolites and energy | neurogenesis | positive regulation of cell adhesion | regulation of organelle organization | cellular response to interleukin-3 | generation of neurons | membrane organization | mesenchyme development | regulation of neuron death | positive regulation of GTPase activity | cellular process | localization | negative regulation of calcineurin-mediated signaling | extrinsic apoptotic signaling pathway | regulation of calcium-mediated signaling | negative regulation of signaling | regulation of dopaminergic neuron differentiation | chemical synaptic transmission | neuron development | positive regulation of protein export from nucleus | canonical Wnt signaling pathway | beta-catenin destruction complex disassembly | negative regulation of apoptotic process | regulation of proteolysis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | regulation of neuron projection development | regulation of canonical Wnt signaling pathway | regulation of protein export from nucleus | negative regulation of cellular metabolic process | tissue development | regulation of binding | regulation of cell differentiation | beta-catenin destruction complex assembly | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | regulation of protein complex assembly | regulation of protein localization to centrosome | positive regulation of cellular protein metabolic process | negative regulation of phosphatase activity | cellular response to organonitrogen compound | establishment of cell polarity | cellular component organization | negative regulation of calcium-mediated signaling | negative regulation of protein localization to nucleus | positive regulation of protein binding | head development | positive regulation of cellular protein catabolic process | response to stimulus | peptidyl-threonine phosphorylation | regulation of cellular protein localization | regulation of cellular response to heat | positive regulation of protein metabolic process | regulation of cellular protein catabolic process | response to stress | cellular polysaccharide metabolic process | positive regulation of cellular protein localization | polysaccharide metabolic process | response to peptide | circadian rhythm | regulation of epithelial cell differentiation | protein serine/threonine kinase activity | programmed cell death | positive regulation of proteolysis involved in cellular protein catabolic process | rhythmic process | positive regulation of proteolysis | regulation of protein transport | regulation of glycogen (starch) synthase activity | G-protein coupled receptor signaling pathway | negative regulation of metabolic process | regulation of cellular component size | cellular component assembly | regulation of axon extension | protein modification process | regulation of peptide transport | regulation of cell adhesion | mitochondrion organization | macromolecule modification | cell-cell signaling | positive regulation of cell-matrix adhesion | regulation of intracellular transport | cell surface receptor signaling pathway involved in cell-cell signaling | positive regulation of mitochondrion organization | regulation of membrane potential | regulation of cellular response to stress | response to nitrogen compound | apoptotic process | system development | glycogen metabolic process | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | Wnt signaling pathway | negative regulation of phosphate metabolic process | multicellular organism development | negative regulation of catalytic activity | phosphorus metabolic process | regulation of axonogenesis | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | regulation of catalytic activity | ER-nucleus signaling pathway | negative regulation of cellular protein localization | telencephalon development | regulation of neuron differentiation | regulation of gene expression | regulation of postsynaptic membrane potential | negative regulation of glycogen (starch) synthase activity | regulation of mitochondrial membrane permeability | cellular response to stress | nervous system process | cellular response to peptide | synaptic signaling | positive regulation of intracellular protein transport | positive regulation of cellular metabolic process | mitochondrial transport | regulation of protein localization to nucleus | protein autophosphorylation | regulation of nitrogen compound metabolic process | regulation of cell-substrate adhesion | cellular carbohydrate metabolic process | positive regulation of protein complex assembly | negative regulation of calcineurin-NFAT signaling cascade | maintenance of cell polarity | negative regulation of binding | positive regulation of hydrolase activity | cellular response to cytokine stimulus | regulation of cellular protein metabolic process | positive regulation of proteasomal protein catabolic process | phosphorylation | carbohydrate metabolic process | positive regulation of neuron death | regulation of GTPase activity | regulation of apoptotic signaling pathway | protein phosphorylation | establishment or maintenance of cell polarity | phosphate-containing compound metabolic process | negative regulation of protein dephosphorylation | regulation of mitochondrion organization | mitochondrial membrane organization | dopamine receptor signaling pathway | cell communication | negative regulation of protein binding | regulation of cellular metabolic process | cellular response to amyloid-beta | regulation of protein metabolic process | positive regulation of signal transduction | limbic system development | positive regulation of establishment of protein localization | positive regulation of transport | cerebral cortex development | apoptotic signaling pathway | ER overload response | regulation of microtubule-based process | negative regulation of epithelial cell differentiation | positive regulation of molecular function | regulation of nucleocytoplasmic transport | regulation of proteasomal ubiquitin-dependent protein catabolic process | negative regulation of glycogen biosynthetic process | neuron differentiation | protein-containing complex assembly | regulation of cell morphogenesis involved in differentiation | negative regulation of carbohydrate metabolic process | protein metabolic process | regulation of establishment of protein localization | regulation of growth | response to organic substance | regulation of protein dephosphorylation | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | regulation of dendrite morphogenesis | cell surface receptor signaling pathway | regulation of glucose metabolic process | cell projection organization | metabolic process | mesenchymal cell differentiation | positive regulation of ubiquitin-dependent protein catabolic process | regulation of protein catabolic process | oxidation-reduction process | regulation of type B pancreatic cell development | negative regulation of programmed cell death | regulation of proteasomal protein catabolic process | positive regulation of cell death | protein kinase activity | neuron projection development | negative regulation of protein complex assembly | positive regulation of cellular component biogenesis | organic substance metabolic process | cell death | negative regulation of biosynthetic process | animal organ development | forebrain development | negative regulation of neuron differentiation | positive regulation of cell-substrate adhesion | pallium development | negative regulation of cellular protein metabolic process | positive regulation of programmed cell death | regulation of calcineurin-NFAT signaling cascade | regulation of Wnt signaling pathway | regulation of phosphate metabolic process | regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | negative regulation of dopaminergic neuron differentiation | positive regulation of binding | positive regulation of intracellular transport | positive regulation of protein transport | negative regulation of protein metabolic process | regulation of dendrite development | regulation of cell communication | regulation of membrane permeability | negative regulation of molecular function | negative regulation of signal transduction | signaling | response to amyloid-beta | regulation of protein binding | cell development | energy reserve metabolic process | regulation of developmental growth | protein-containing complex disassembly | extrinsic apoptotic signaling pathway in absence of ligand | cellular protein metabolic process | regulation of cell size | negative regulation of phosphoprotein phosphatase activity | positive regulation of protein localization to centrosome | response to biotic stimulus | regulation of nervous system development | regulation of developmental process | regulation of phosphoprotein phosphatase activity | energy derivation by oxidation of organic compounds | kinase activity | developmental process | negative regulation of canonical Wnt signaling pathway | organelle organization | cellular glucan metabolic process | regulation of cell growth | peptidyl-serine phosphorylation | cellular protein modification process | regulation of transport | negative regulation of protein acetylation | response to organonitrogen compound | negative regulation of dephosphorylation | regulation of glycogen biosynthetic process | negative regulation of hydrolase activity | central nervous system development | regulation of generation of precursor metabolites and energy | positive regulation of metabolic process | negative regulation of Wnt signaling pathway | regulation of cell projection organization | cellular metabolic process | cellular response to organic substance | regulation of protein localization | regulation of cell death | negative regulation of cell death | negative regulation of cell development | regulation of ubiquitin-dependent protein catabolic process | positive regulation of nucleocytoplasmic transport | regulation of microtubule cytoskeleton organization | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of apoptotic signaling pathway | regulation of cytoskeleton organization | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | regulation of glycogen metabolic process | regulation of cell-matrix adhesion | macromolecule metabolic process | negative regulation of neurogenesis | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
dendrite | intracellular membrane-bounded organelle | synapse | neuron projection | somatodendritic compartment | Wnt signalosome | microtubule organizing center | cell | nuclear lumen | cytoplasm | intracellular organelle | dendritic tree | centrosome | protein-containing complex | cell projection | postsynapse | nucleoplasm | plasma membrane | microtubule cytoskeleton | mitochondrion | beta-catenin destruction complex | membrane-bounded organelle | nucleus | organelle | cell periphery | axon | membrane-enclosed lumen | cytosol | cytoskeleton | intracellular | membrane
