QuickView for IL11;jsessionid=7D7097839D498408F891CF080E343E5F (gene)

Gene Symbol:

IL11 Homo sapiens

Full name:

interleukin 11

Synonyms:

AGIF, IL-11, interleukin-11, adipogenesis inhibitory factor, oprelvekin

Genomic Location:

Chr 19: 60567569-60573626

Description:

The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cel...

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The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  IRF1_01 ,  AP1_C ,  TGANTCA_AP1_C ,  DR3_Q4 ,  ZIC1_01 ,  VDR_Q3 ,  AP2GAMMA_01 ,  ZIC3_01 ,  AP2ALPHA_01 ,  TGACCTY_ERR1_Q2 ,  GGGAGGRR_MAZ_Q6 ,  TFIII_Q6 ,  AP1_01 ,  PXR_Q2 ,  AP2_Q6_01 ,  BACH2_01 ,  ATF3_Q6 ,  GGGCGGR_SP1_Q6 ,  AP1_Q2_01 ,  CCCNNGGGAR_OLF1_01 ,  AP2_Q3 ,  AATGTGA_MIR23A_MIR23B ,  BACH1_01 ,  ARGGGTTAA_UNKNOWN ,  TATA_01 ,  ZIC2_01 ,  CAGCTG_AP4_Q5 ,  AACTTT_UNKNOWN ,  AP4_Q5 ,  DR4_Q2 ,  AP1_Q4_01 ,  IRF2_01 ,  CP2_01 ,  OLF1_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-323

Cytogenetic Map:

19q13.42

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