QuickView for KCNQ2 (gene)

Gene Symbol:

KCNQ2 Homo sapiens

Full name:

potassium voltage-gated channel subfamily Q member 2

Synonyms:

BFNC, EBN, EBN1, ENB1, HNSPC, KCNA11, KV7.2, potassium voltage-gated channel subfamily KQT member 2, neuroblastoma-specific potassium channel subunit alpha KvLQT2, potassium channel, voltage gated KQT-like subfamily Q, member 2, voltage-gated potassium channel subunit Kv7.2

Genomic Location:

Chr 20: 61507986-61574437

Description:

The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscar...

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The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Bos taurus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGCCTTA_MIR124A ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  TGCACTT_MIR519C_MIR519B_MIR519A

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-188

Cytogenetic Map:

20q13.33

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