QuickView for LAB300 (gene)

Gene Symbol:

LRBA Homo sapiens

Full name:

LPS responsive beige-like anchor protein

Synonyms:

BGL, CDC4L, CVID8, LAB300, LBA, lipopolysaccharide-responsive and beige-like anchor protein, CDC4-like protein, LPS-responsive vesicle trafficking, beach and anchor containing, vesicle trafficking, beach and anchor containing

Genomic Location:

Chr 4: 151405044-152156329

Description:

The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/o...

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The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  TTTGTAG_MIR520D ,  CTTTGTA_MIR524 ,  ATTCTTT_MIR186 ,  CAGCTG_AP4_Q5

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-143 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-495

Cytogenetic Map:

4q31.3

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