QuickView for LMO2 (gene)
- Gene Symbol:
- LMO2
Homo sapiens - Full name:
- LIM domain only 2
- Synonyms:
- LMO-2, RBTN2, RBTNL1, RHOM2, TTG2, rhombotin-2, LIM domain only protein 2, T-cell translocation gene 2, T-cell translocation protein 2, cysteine-rich protein TTG-2, rhombotin-like 1
- Genomic Location:
- Chr 11: 33836698-33870412
- Description:
-
LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Gallus gallus , Canis lupus familiaris , Bos taurus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
TGGAAA_NFAT_Q4_01 , TTANTCA_UNKNOWN , AREB6_02 , GATA_Q6 , GATA_C , AACTGAC_MIR223 , HOXA3_01 , GATAAGR_GATA_C , GATA1_04 , AML1_01
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
11p13
GO Molecular Function
sequence-specific DNA binding | transcription factor activity, transcription factor binding | transcription regulatory region DNA binding | cofactor binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | cation binding | transcription factor activity, RNA polymerase II transcription factor binding | proximal promoter sequence-specific DNA binding | RNA polymerase II activating transcription factor binding | nucleic acid binding | RNA polymerase II regulatory region DNA binding | E-box binding | bHLH transcription factor binding | DNA binding | sequence-specific double-stranded DNA binding | ion binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | transcriptional activator activity, RNA polymerase II transcription factor binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | RNA polymerase II transcription factor binding | activating transcription factor binding | RNA polymerase II regulatory region sequence-specific DNA binding | metal ion binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | transcription factor activity, transcription factor binding | positive regulation of macromolecule biosynthetic process | regulation of immune system process | response to hormone | RNA polymerase II transcription factor activity, sequence-specific DNA binding | regulation of hematopoietic progenitor cell differentiation | positive regulation of cellular biosynthetic process | cellular process | positive regulation of nitrogen compound metabolic process | transcription factor activity, RNA polymerase II transcription factor binding | regulation of cell differentiation | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | response to stimulus | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | positive regulation of RNA biosynthetic process | mRNA metabolic process | cellular biosynthetic process | regulation of nucleic acid-templated transcription | cellular response to hormone stimulus | nitrogen compound metabolic process | multicellular organism development | mRNA transcription by RNA polymerase II | regulation of hematopoietic stem cell differentiation | regulation of gene expression | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | biosynthetic process | aromatic compound biosynthetic process | regulation of cellular metabolic process | mRNA transcription | regulation of RNA metabolic process | regulation of stem cell differentiation | transcriptional activator activity, RNA polymerase II transcription factor binding | cellular response to thyroid hormone stimulus | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | response to organic substance | regulation of hemopoiesis | anatomical structure development | metabolic process | regulation of RNA biosynthetic process | nucleobase-containing compound metabolic process | organic substance metabolic process | gene expression | transcription, DNA-templated | regulation of transcription, DNA-templated | cellular macromolecule biosynthetic process | regulation of developmental process | developmental process | response to thyroid hormone | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | cellular metabolic process | cellular response to organic substance | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | transcription factor complex | intracellular organelle | protein-containing complex | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular
