QuickView for LOX;jsessionid=F72C99E8335D812E716B4F224D4ED806 (gene)

Gene Symbol:

LOX Homo sapiens

Full name:

lysyl oxidase

Synonyms:

AAT10, protein-lysine 6-oxidase

Genomic Location:

Chr 5: 121429918-121441853

Description:

This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the cross...

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This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  PR_Q2 ,  IRF1_01 ,  PR_02 ,  TTANTCA_UNKNOWN ,  TGGNNNNNNKCCAR_UNKNOWN ,  POU3F2_01 ,  YTATTTTNR_MEF2_02 ,  SMAD3_Q6 ,  AAANWWTGC_UNKNOWN ,  EVI1_04 ,  IPF1_Q4 ,  AACTGGA_MIR145 ,  IRF1_Q6 ,  GR_Q6_01 ,  WTGAAAT_UNKNOWN ,  AR_02 ,  CDX2_Q5 ,  GR_Q6 ,  TATA_C ,  NF1_Q6_01 ,  OCT1_06 ,  HLF_01 ,  OCT1_02 ,  POU3F2_02 ,  TTGTTT_FOXO4_01 ,  GR_01 ,  IRF7_01 ,  TEF_Q6 ,  CTTTGT_LEF1_Q2 ,  GCTNWTTGK_UNKNOWN ,  AACTTT_UNKNOWN ,  ER_Q6 ,  PAX2_02 ,  FREAC4_01 ,  FOXO4_02

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-145

Cytogenetic Map:

5q23.1

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