Bookmark
Forward
QuickView for Levorphanol (compound)
PubChem
| Name: | Levorphanol |
|---|---|
| PubChem Compound ID: | 11957532 |
| Description: | A narcotic analgesic that may be habit-forming. It is nearly as effective orally as by injection. |
| Molecular formula: | C21H29NO7 |
| Molecular weight: | 407.458 g/mol |
| Synonyms: |
EU-0100447
|
DrugBank
Identification
| Name: | Levorphanol |
|---|---|
| Name (isomeric): | DB00854 |
| Drug Type: | small molecule |
| Description: | A narcotic analgesic that may be habit-forming. It is nearly as effective orally as by injection. |
| Synonyms: |
Racemorfano [INN-Spanish]; Levorphanal; Dea No. 9733; Levorphanol Tartrate; Methorphinan; Racemethorphanum; Levorfanol [INN-Spanish]; Levorphanol Dl-Form; Levorphan; Levorfanolo [Dcit].
show more » |
| Brand: | Racemic Dromoran, Lemoran, Antalgin, Levo-Dromoran, Dromoran, Cetarin, Aromarone |
| Category: | Narcotics, Analgesics, Opioid |
| CAS number: | 77-07-6 |
Pharmacology
| Indication: | For the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate |
|---|---|
| Pharmacology: |
Levorphanol is a potent synthetic opioid analgesic indicated for the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate. Levorphanol is similar to morphine in its actions, however it is up to 8 times more potent than morphine. Levorphanol produces a degree of respiratory depression similar...
show more » |
| Mechanism of Action: | Like other mu-agonist opioids it is believed to act at receptors in the periventricular and periaqueductal gray matter in both the brain and spinal cord to alter the transmission and perception of pain. |
| Absorption: | Levorphanol is well absorbed after PO administration with peak plasma concentrations occurring approximately 1 hour after dosing. |
| Protein binding: | 40% |
| Biotransformation: | Levorphanol is extensively metabolized in the liver and is eliminated as the glucuronide metabolite. |
| Half Life: | 11-16 hours |
| Clearance: | 0.78 to 1.1 L/kg/hr |
| Toxicity: | LD50=150 mg/kg (orally in rats). Signs of overdose include nausea, emesis, dizziness, respiratory depression, hypotension, urinary retention, cardiac arrhythmias, allergic reactions, skin rash, and uticaria. |
| Affected organisms: | Humans and other mammals |
Interactions
| Food interaction: |
| ||
|---|---|---|---|
| Drug interaction: |
|
Targets
