QuickView for MEP1B (gene)

Gene Symbol:

MEP1B Homo sapiens

Full name:

meprin A subunit beta

Synonyms:

meprin A subunit beta, N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta, N-benzoyl-L-tyrosyl-p-amino-benzoic acid hydrolase beta subunit, PABA peptide hydrolase, PPH beta, endopeptidase-2, meprin A, beta, meprin B

Genomic Location:

Chr 18: 28023985-28054365

Description:

Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomer...

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Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Cytogenetic Map:

18q12.1

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