QuickView for METAP2 (gene)

Gene Symbol:

METAP2 Homo sapiens

Full name:

methionyl aminopeptidase 2

Synonyms:

MAP2, MNPEP, p67eIF2, methionine aminopeptidase 2, eIF-2-associated p67 homolog, initiation factor 2-associated 67 kDa glycoprotein, peptidase M 2, testicular tissue protein Li 17

Genomic Location:

Chr 12: 94391953-94433746

Description:

The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with va...

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The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RTAAACA_FREAC2_01 ,  AAAGACA_MIR511 ,  SCGGAAGY_ELK1_02 ,  TGCTTTG_MIR330 ,  CTAGGAA_MIR384 ,  CEBPGAMMA_Q6

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-378* ,  Predicted Gene Targets for miR-384

Cytogenetic Map:

12q22

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