QuickView for MGST1 (gene)

Gene Symbol:

MGST1 Homo sapiens

Full name:

microsomal glutathione S-transferase 1

Synonyms:

GST12, MGST, MGST-I, microsomal glutathione S-transferase 1, glutathione S-transferase 12, microsomal GST-1, microsomal GST-I

Genomic Location:

Chr 12: 16391343-16408611

Description:

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellul...

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The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NF1_Q6 ,  NF1_Q6_01 ,  TGTTTGY_HNF3_Q6 ,  NRF2_Q4 ,  AACTTT_UNKNOWN ,  TCF11MAFG_01

Cytogenetic Map:

12p12.3

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