QuickView for MSTN;jsessionid=E9CCEBBE2AA7BD8E1BB3A3343B1AAF7B (gene)
- Gene Symbol:
- MSTN
Homo sapiens - Full name:
- myostatin
- Synonyms:
- GDF8, MSLHP, growth/differentiation factor 8
- Genomic Location:
- Chr 2: 190628671-190635700
- Description:
-
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subuni...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Gallus gallus , Canis lupus familiaris , Pan troglodytes , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
2q32.2
GO Molecular Function
transforming growth factor beta receptor binding | signaling receptor binding | carbohydrate derivative binding | cytokine receptor binding | molecular function regulator | anion binding | identical protein binding | ion binding | heparin binding | protein binding | protein homodimerization activity | receptor regulator activity | protein dimerization activity | growth factor activity | receptor ligand activity | cytokine activity | glycosaminoglycan binding
GO Biological Process
negative regulation of phosphorylation | SMAD protein signal transduction | regulation of muscle system process | negative regulation of cellular response to insulin stimulus | negative regulation of skeletal muscle tissue growth | positive regulation of macromolecule biosynthetic process | regulation of programmed cell death | negative regulation of skeletal muscle satellite cell proliferation | response to hormone | negative regulation of cellular process | negative regulation of kinase activity | response to dexamethasone | cell differentiation | negative regulation of satellite cell differentiation | response to drug | positive regulation of phosphate metabolic process | striated muscle atrophy | response to antibiotic | regulation of skeletal muscle cell differentiation | positive regulation of cellular biosynthetic process | cellular process | negative regulation of muscle organ development | cellular homeostasis | negative regulation of signaling | developmental growth | negative regulation of developmental growth | positive regulation of pathway-restricted SMAD protein phosphorylation | regulation of skeletal muscle cell proliferation | multicellular organismal reproductive process | regulation of striated muscle tissue development | response to growth factor | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | tissue development | regulation of cell differentiation | muscle structure development | anatomical structure homeostasis | regeneration | negative regulation of muscle hypertrophy | regulation of protein kinase B signaling | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | regulation of skeletal muscle satellite cell proliferation | positive regulation of cellular protein metabolic process | response to gravity | response to transforming growth factor beta | response to stimulus | positive regulation of protein metabolic process | cellular response to xenobiotic stimulus | response to stress | regulation of skeletal muscle tissue growth | regulation of cell proliferation | ovulation cycle | reproduction | response to alcohol | response to temperature stimulus | rhythmic process | cellular response to organic cyclic compound | negative regulation of muscle tissue development | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | molecular function regulator | response to ethanol | regulation of nucleic acid-templated transcription | cellular response to hormone stimulus | regulation of skeletal muscle tissue development | system development | reproductive process | regulation of signal transduction | negative regulation of growth | negative regulation of phosphate metabolic process | multicellular organism development | negative regulation of catalytic activity | response to activity | regulation of MAPK cascade | regulation of catalytic activity | regulation of phosphorylation | wound healing | regulation of gene expression | response to ketone | response to lipid | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | negative regulation of insulin receptor signaling pathway | response to corticosteroid | negative regulation of myoblast differentiation | negative regulation of protein kinase B signaling | regulation of cellular protein metabolic process | muscle cell cellular homeostasis | cellular response to glucocorticoid stimulus | response to toxic substance | response to xenobiotic stimulus | cellular response to corticosteroid stimulus | ovulation cycle process | cellular response to drug | response to estrogen | cell communication | regulation of cellular metabolic process | skeletal muscle atrophy | response to testosterone | transmembrane receptor protein serine/threonine kinase signaling pathway | regulation of protein metabolic process | positive regulation of signal transduction | negative regulation of striated muscle tissue development | homeostatic process | regulation of protein phosphorylation | regulation of RNA metabolic process | negative regulation of skeletal muscle cell differentiation | cellular response to transforming growth factor beta stimulus | negative regulation of myoblast proliferation | multicellular organism reproduction | regulation of signaling receptor activity | receptor regulator activity | skeletal muscle adaptation | positive regulation of protein modification process | regulation of growth | response to organic substance | regulation of kinase activity | response to wounding | response to antineoplastic agent | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | growth factor activity | regulation of RNA biosynthetic process | regulation of myoblast differentiation | regulation of myoblast proliferation | negative regulation of skeletal muscle tissue development | receptor ligand activity | cytokine activity | animal organ development | regulation of insulin receptor signaling pathway | muscle atrophy | response to heat | regulation of cellular response to insulin stimulus | regulation of phosphate metabolic process | cellular response to steroid hormone stimulus | cellular response to dexamethasone stimulus | transforming growth factor beta receptor signaling pathway | skeletal muscle tissue regeneration | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | cell development | regulation of developmental growth | positive regulation of phosphorylation | regulation of developmental process | developmental process | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | positive regulation of nucleic acid-templated transcription | response to electrical stimulus | positive regulation of metabolic process | cellular response to organic substance | regulation of cell death | response to steroid hormone | tissue regeneration | negative regulation of cell differentiation | muscle organ development | muscle system process | positive regulation of signaling | signal transduction | regulation of signaling | response to muscle activity | regulation of pathway-restricted SMAD protein phosphorylation | positive regulation of gene expression | response to glucocorticoid | cellular response to growth factor stimulus | regulation of muscle organ development | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
cell | cytoplasm | extracellular region | extracellular space | intracellular
