QuickView for Methacholine (compound)

Summary
General Info

PubChem

PubChem Compound 1993

Name:	Methacholine Chloride
PubChem Compound ID:	1993
Description:	A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)
Molecular formula:	C₈H₁₈NO₂⁺
Molecular weight:	160.234 g/mol
Synonyms:	62-51-1; beta-Methylacetylcholine; Methacholin; 1-Propanaminium, 2- (acetyloxy)-N,N,N-trimethyl-, iodide; Acetyl-beta-methylcholine; AMMONIUM, (2-HYDROXYPROPYL)TRIMETHYL-, ACETATE (ESTER); Mecholyl iodide; 1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; Acetylmethylcholine; BRN 1769932. show more » 62-51-1; beta-Methylacetylcholine; Methacholin; 1-Propanaminium, 2- (acetyloxy)-N,N,N-trimethyl-, iodide; Acetyl-beta-methylcholine; AMMONIUM, (2-HYDROXYPROPYL)TRIMETHYL-, ACETATE (ESTER); Mecholyl iodide; 1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; Acetylmethylcholine; BRN 1769932; Methacholine; C07471; 625-19-4; Mecholine; 55-92-5; Ammonium, (2-hydroxypropyl)trimethyl-, iodide, acetate; Methacholine iodide; 2-acetyloxy-N,N,N-trimethylpropan-1-aminium; Choline, acetyl-beta-methyl-; Mecholin; Prestwick0_000759; MCH; SPBio_002717; Methacholinum; CHEBI:6804; Prestwick1_000759; NSC281057 show less «

DrugBank

Identification

Name:	Methacholine Chloride
Name (isomeric):	DB06709
Drug Type:	small molecule
Description:	A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)
Brand:	Provocholine
CAS number:	55-92-5

Pharmacology

Indication:	It is most commonly used for diagnosing bronchial hyperreactivity, using the bronchial challenge test.
Pharmacology:	Methacholine acts as a non-selective muscarinic receptor agonist to stimulate the parasympathetic nervous system. It is highly active at all of the muscarinic receptors
Mechanism of Action:	By agonizing the muscarinic receptors, this drug induces bronchoconstriction. This bronchoconstriction is used as a test in asthmatics and in bronchial hyperreactivity.

Interactions

Drug interaction:

Betaxolol

Beta-Blockers like betaxolol may worsen brochoconstriction and decrease the effectiveness of agents used to treat the resulting bronchoconstriction. Use of betaxolol and methacholine concomitantly is contraindicated.

Targets

Muscarinic acetylcholine receptor M3