QuickView for Methyclothiazide (compound)

Methycyclothiazide; Meticlotiazida [INN-Spanish]; 6-Chloro-3-chloromethyl-2-methyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide; Eutron; Enduronyl; Enduron; Enduronum; AIDS126446; Aquatensen; NSC-110431.
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Methycyclothiazide; Meticlotiazida [INN-Spanish]; 6-Chloro-3-chloromethyl-2-methyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide; Eutron; Enduronyl; Enduron; Enduronum; AIDS126446; Aquatensen; NSC-110431; Enduron (TN); 6-Chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 135-07-9; Methyclothiazidum [INN-Latin]; BRN 0765361; AIDS-126446; D00656; Aquaresen; Methychlothiazide; Meticlotiazide [DCIT]; Methylcyclothiazide; 96782-90-0; NSC110431; 6-Chloro-3-(chloromethyl)-2-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; Naturon (VAN); Diutensen-R; EINECS 205-172-2; NSC 110431; 6-Chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2H-1,2, 4-benzothiadiazine-7-sulfonamide 1,1-dioxide; Methylchlorothiazide; Duretic; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-, 1,1-dioxide; Methylclothiazide; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3- (chloromethyl)-3,4-dihydro-2-methyl-, 1,1-dioxide; HSDB 3363; Methyclothiazide [USAN:BAN:INN:JAN]; Naturon; Ciba 7272-Su; Methyclothiazid; Methyclothiazide (JAN/USP); CI-625; Methyclothiazide; C07765
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Methycyclothiazide; Methylclothiazide; Methychlothiazide; Methyclothiazid; Methylcyclothiazide; Methylchlorothiazide

Methyclothiazide, a diuretic-antihypertensive agent, is a member of the benzothiadiazine (thiazide) class of drugs. Methyclothiazide has a per mg natriuretic activity approximately 100 times that of the prototype thiazide, chlorothiazide. At maximal therapeutic dosages, all thiazides are approximately equal in their diuretic/natriuretic effects. Li...
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Methyclothiazide, a diuretic-antihypertensive agent, is a member of the benzothiadiazine (thiazide) class of drugs. Methyclothiazide has a per mg natriuretic activity approximately 100 times that of the prototype thiazide, chlorothiazide. At maximal therapeutic dosages, all thiazides are approximately equal in their diuretic/natriuretic effects. Like other benzothiadiazines, methyclothiazide also has antihypertensive properties, and may be used for this purpose either alone or to enhance the antihypertensive action of other drugs.
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Methyclothiazide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle, altering electrolyte transfer in the proximal tubule. This results in excretion of sodium, chloride, and water and, hence, diuresis. As a diuretic, methyclothiazide inhibits active chloride reabsorption at the early distal tubul...
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Methyclothiazide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle, altering electrolyte transfer in the proximal tubule. This results in excretion of sodium, chloride, and water and, hence, diuresis. As a diuretic, methyclothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like methyclothiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of methyclothiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle.
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