QuickView for Monocarboxylate transporter (biogroup)

Description:: Monocarboxylate transporters (MCTs) catalyse the proton-linked transport of monocarboxylates such as L-lactate, pyruvate, and the ketone bodies across the plasma membrane. All of the MCT family (also known as SLC16 solute carrier family) members share conserved sequence motifs. They are are predicted to have 12-transmembrane helices (TMs) with intracellular C and N termini and a large cytosolic loop between TMs 6 and 7. Four mammalian isoforms, MCTs 1-4, have been identified, each with distinct substrate and inhibitor affinities. MCT1-4 have been linked to cancer maintenance and aggressiveness.
Taxonomy/Path:: InterPro : Major facilitator superfamily / Monocarboxylate transporter

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