QuickView for NLGN1;jsessionid=FAEB2875B76C697D316B81C46AEA1DB9 (gene)
- Gene Symbol:
- NLGN1
Homo sapiens - Full name:
- neuroligin 1
- Synonyms:
- NL1, neuroligin-1
- Genomic Location:
- Chr 3: 174598938-175483810
- Description:
-
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses.
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-15 , Predicted Gene Targets for miR-190 , Predicted Gene Targets for miR-193 , Predicted Gene Targets for miR-217 , Predicted Gene Targets for miR-30 , Predicted Gene Targets for miR-369-3p , Predicted Gene Targets for miR-381 , Predicted Gene Targets for miR-448 , Predicted Gene Targets for miR-374 , Predicted Gene Targets for miR-493-5p
- Cytogenetic Map:
-
3q26.31
GO Molecular Function
peptide binding | amyloid-beta binding | signaling receptor binding | neurexin family protein binding | protein domain specific binding | amide binding | signaling receptor activity | scaffold protein binding | cell adhesion molecule binding | protein binding | protein dimerization activity | PDZ domain binding
GO Biological Process
synaptic vesicle exocytosis | protein homooligomerization | cell morphogenesis | positive regulation of circadian rhythm | regulation of AMPA receptor activity | positive regulation of behavior | exocytosis | protein heterotetramerization | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | positive regulation of cellular component organization | regulation of cell morphogenesis | regulation of protein localization to synapse | positive regulation of filopodium assembly | regulation of neurogenesis | neuron projection morphogenesis | neurotransmitter secretion | regulation of cellular localization | regulation of synapse assembly | positive regulation of presynapse assembly | regulation of cell development | regulation of localization | neuron projection arborization | establishment of localization | positive regulation of protein localization to synapse | negative regulation of cellular process | positive regulation of neurotransmitter secretion | positive regulation of developmental process | response to metal ion | cell differentiation | negative regulation of dendrite development | nervous system development | AMPA glutamate receptor clustering | cell part morphogenesis | neurogenesis | generation of neurons | membrane organization | membrane biogenesis | intracellular transport | regulation of circadian sleep/wake cycle | positive regulation of neurological system process | cellular process | secretion | establishment of organelle localization | regulation of dendritic spine morphogenesis | localization | cell projection morphogenesis | neurotransmitter-gated ion channel clustering | positive regulation of synaptic transmission | regulation of respiratory gaseous exchange | protein transport | cytoskeletal matrix organization at active zone | negative regulation of synapse organization | chemical synaptic transmission | neuron development | synapse assembly | positive regulation of ruffle assembly | macromolecule localization | regulation of neuron projection development | response to inorganic substance | establishment of localization in cell | regulation of behavior | regulation of neurological system process | regulation of cell differentiation | terminal button organization | regulation of cellular process | organelle localization | cellular component organization | regulation of respiratory gaseous exchange by neurological system process | negative regulation of cell morphogenesis involved in differentiation | cellular response to metal ion | response to stimulus | neurexin clustering involved in presynaptic membrane assembly | positive regulation of circadian sleep/wake cycle, wakefulness | positive regulation of synaptic vesicle recycling | negative regulation of dendritic spine morphogenesis | intracellular protein transport | negative regulation of neuron projection development | positive regulation of synaptic vesicle exocytosis | postsynaptic membrane assembly | receptor clustering | regulation of neurotransmitter receptor activity | cellular response to inorganic substance | cellular localization | secretion by cell | rhythmic process | cellular component assembly | regulation of synapse structure or activity | modulation of chemical synaptic transmission | presynaptic membrane assembly | positive regulation of synaptic transmission, glutamatergic | vesicle targeting | cell-cell signaling | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules | regulation of intracellular transport | regulation of membrane potential | positive regulation of exocytosis | regulation of neurotransmitter levels | synaptic vesicle cycle | regulation of cell projection assembly | system development | regulation of signal transduction | modulation of excitatory postsynaptic potential | positive regulation of neuron projection development | multicellular organism development | regulation of synaptic transmission, GABAergic | regulation of synaptic transmission, glutamatergic | negative regulation of dendritic spine development | regulation of synaptic vesicle exocytosis | protein complex oligomerization | neuron cell-cell adhesion | localization within membrane | synaptic vesicle recycling | regulation of neuron differentiation | positive regulation of presynaptic active zone assembly | protein localization to membrane | positive regulation of secretion | organic substance transport | nervous system process | membrane assembly | synaptic signaling | regulation of synapse organization | positive regulation of cell projection organization | peptide transport | positive regulation of intracellular signal transduction | vesicle-mediated transport | regulation of circadian sleep/wake cycle, wakefulness | synapse organization | positive regulation of cell differentiation | synaptic membrane adhesion | establishment of vesicle localization | negative regulation of dendrite morphogenesis | regulation of synaptic vesicle clustering | regulated exocytosis | regulation of synaptic vesicle endocytosis | protein tetramerization | regulation of synaptic vesicle transport | positive regulation of dendritic spine development | postsynapse assembly | positive regulation of regulated secretory pathway | receptor localization to synapse | glutamate receptor clustering | protein localization to synapse | cell communication | presynaptic membrane organization | synaptic vesicle endocytosis | regulation of respiratory system process | protein-containing complex localization | retrograde trans-synaptic signaling by trans-synaptic protein complex | positive regulation of signal transduction | positive regulation of synaptic transmission, GABAergic | postsynaptic density protein 95 clustering | postsynaptic membrane organization | positive regulation of synapse assembly | positive regulation of transport | regulation of filopodium assembly | positive regulation of dendrite development | neuron differentiation | presynapse assembly | regulation of signaling receptor activity | protein-containing complex assembly | regulation of cell morphogenesis involved in differentiation | cellular response to calcium ion | NMDA glutamate receptor clustering | negative regulation of cell projection organization | import into cell | regulation of intracellular signal transduction | regulation of exocytosis | anatomical structure development | regulation of dendrite morphogenesis | positive regulation of neurogenesis | cell projection organization | positive regulation of cell development | positive regulation of calcium ion-dependent exocytosis | cellular protein localization | amide transport | regulation of vesicle-mediated transport | calcium ion regulated exocytosis | endocytosis | neuronal signal transduction | regulation of secretion | cell adhesion | regulation of ruffle assembly | neuron projection development | positive regulation of cellular component biogenesis | negative regulation of neuron differentiation | cytoskeleton organization | synaptic vesicle targeting | regulation of ion transmembrane transport | establishment of protein localization | cell-cell adhesion | regulation of regulated secretory pathway | positive regulation of intracellular transport | regulation of postsynapse organization | positive regulation of excitatory postsynaptic potential | excitatory synapse assembly | synaptic vesicle clustering | regulation of dendrite development | regulation of cell communication | regulation of dendritic spine development | signaling | cell development | regulation of endocytosis | synaptic vesicle localization | regulation of transmembrane transporter activity | positive regulation of synaptic vesicle clustering | protein localization | regulation of ion transmembrane transporter activity | protein heterooligomerization | anatomical structure morphogenesis | cellular macromolecule localization | positive regulation of plasma membrane bounded cell projection assembly | regulation of NMDA receptor activity | regulation of synaptic vesicle recycling | regulation of circadian rhythm | regulation of nervous system development | regulation of developmental process | regulation of ion transport | developmental process | organelle organization | cortical cytoskeleton organization | regulation of transport | neurotransmitter transport | regulation of cation channel activity | signal release | regulation of glutamate receptor signaling pathway | regulation of calcium ion-dependent exocytosis | response to calcium ion | cell-cell adhesion via plasma-membrane adhesion molecules | regulation of synaptic plasticity | vesicle localization | positive regulation of neuron differentiation | protein targeting | regulation of cell projection organization | long-term synaptic potentiation | synaptic vesicle transport | regulation of protein localization | negative regulation of cell development | postsynaptic density organization | positive regulation of endocytosis | positive regulation of synaptic vesicle endocytosis | negative regulation of cell differentiation | regulation of cellular component organization | retrograde trans-synaptic signaling | regulation of presynapse assembly | positive regulation of signaling | signal transduction | regulation of signaling | regulation of neurotransmitter secretion | negative regulation of neurogenesis | multicellular organismal process
GO Cellular Component
dendritic spine | integral component of membrane | dendrite | intracellular membrane-bounded organelle | synapse | spanning component of membrane | neuron projection | somatodendritic compartment | actin-based cell projection | cell | plasma membrane protein complex | intrinsic component of membrane | synaptic membrane | external side of plasma membrane | cytoplasm | intracellular organelle | NMDA selective glutamate receptor complex | receptor complex | dendritic tree | presynapse | Golgi apparatus | protein-containing complex | cell projection | postsynaptic membrane | endomembrane system | neuron spine | postsynapse | plasma membrane | postsynaptic density | asymmetric synapse | integral component of postsynaptic membrane | integral component of plasma membrane | asymmetric, glutamatergic, excitatory synapse | membrane-bounded organelle | dendritic shaft | filopodium | organelle | postsynaptic specialization | glutamatergic synapse | cell periphery | excitatory synapse | ionotropic glutamate receptor complex | transmembrane transporter complex | filopodium tip | cation channel complex | ion channel complex | cell surface | intracellular | cell junction | membrane | intrinsic component of plasma membrane
