QuickView for NR3C2;jsessionid=BC0A2FDB3FBB40803889F8C37DF674F4 (gene)

Gene Symbol:

NR3C2 Homo sapiens

Full name:

nuclear receptor subfamily 3 group C member 2

Synonyms:

MCR, MLR, MR, NR3C2VIT, mineralocorticoid receptor, aldosterone receptor, mineralocorticoid receptor 1, mineralocorticoid receptor 2, mineralocorticoid receptor delta, nuclear receptor subfamily 3, group C, member 2 variant 3

Genomic Location:

Chr 4: 149219370-149582973

Description:

This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseu...

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This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFAT_Q4_01 ,  TGGAAA_NFAT_Q4_01 ,  IRF1_01 ,  CMYB_01 ,  TTTGCAG_MIR518A2 ,  GATA1_03 ,  AAGCCAT_MIR135A_MIR135B ,  TTANTCA_UNKNOWN ,  OCT1_04 ,  HFH3_01 ,  NFAT_Q6 ,  AML_Q6 ,  E2F1_Q4_01 ,  YTATTTTNR_MEF2_02 ,  CTTTGCA_MIR527 ,  YATTNATC_UNKNOWN ,  LYF1_01 ,  TTGCACT_MIR130A_MIR301_MIR130B ,  FAC1_01 ,  IRF1_Q6 ,  GGGCATT_MIR365 ,  AAGCAAT_MIR137 ,  MYB_Q5_01 ,  CDPCR3HD_01 ,  FOXO3_01 ,  CAGGTA_AREB6_01 ,  GGATTA_PITX2_Q2 ,  CAGGTG_E12_Q6 ,  PXR_Q2 ,  CCAWYNNGAAR_UNKNOWN ,  ATTCTTT_MIR186 ,  GCAAAAA_MIR129 ,  CDPCR1_01 ,  GGGCGGR_SP1_Q6 ,  ATGTTAA_MIR302C ,  TGCTGAY_UNKNOWN ,  GGCNRNWCTTYS_UNKNOWN ,  GCAAGAC_MIR431 ,  CTTTAAR_UNKNOWN ,  TGCCAAR_NF1_Q6 ,  E2F_03 ,  E2F_Q4_01 ,  MYB_Q6 ,  GTGCCTT_MIR506 ,  USF_Q6_01 ,  TTGTTT_FOXO4_01 ,  AP2REP_01 ,  RGAGGAARY_PU1_Q6 ,  IK1_01 ,  CTGCAGY_UNKNOWN ,  CTGYNNCTYTAA_UNKNOWN ,  TGACAGNY_MEIS1_01 ,  CTTTGT_LEF1_Q2 ,  CAGCTG_AP4_Q5 ,  SRY_02 ,  BRN2_01 ,  AACTTT_UNKNOWN ,  ACCTGTTG_UNKNOWN ,  E2F_Q3_01 ,  STTTCRNTTT_IRF_Q6 ,  IRF2_01 ,  LMO2COM_01 ,  MYB_Q3

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-205 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-338 ,  Predicted Gene Targets for miR-365 ,  Predicted Gene Targets for miR-431 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-450 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-137 ,  Predicted Gene Targets for miR-140 ,  Predicted Gene Targets for miR-31 ,  Predicted Gene Targets for miR-455 ,  Predicted Gene Targets for miR-505

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Cytogenetic Map:

4q31.23

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