QuickView for Nck1 (gene)
- Gene Symbol:
- NCK1
Homo sapiens - Full name:
- NCK adaptor protein 1
- Synonyms:
- NCK, NCKalpha, nck-1, cytoplasmic protein NCK1, NCK tyrosine kinase, SH2/SH3 adaptor protein NCK-alpha, melanoma NCK protein, non-catalytic region of tyrosine kinase
- Genomic Location:
- Chr 3: 138063763-138150658
- Description:
-
The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encod...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
3q22.3
GO Molecular Function
structural molecule activity | ephrin receptor binding | kinase binding | translation initiation factor binding | protein kinase regulator activity | receptor signaling complex scaffold activity | cytoskeletal adaptor activity | cadherin binding | eukaryotic initiation factor eIF2 binding | kinase regulator activity | protein kinase inhibitor activity | protein kinase binding | receptor tyrosine kinase binding | enzyme binding | enzyme inhibitor activity | signaling receptor binding | molecular function regulator | signaling adaptor activity | protein domain specific binding | cytoskeletal protein binding | protein binding, bridging | protein tyrosine kinase binding | molecular adaptor activity | cell adhesion molecule binding | protein binding | kinase inhibitor activity | protein-containing complex scaffold activity | SH3/SH2 adaptor activity | enzyme regulator activity
GO Biological Process
positive regulation of immune response | negative regulation of phosphorylation | regulation of supramolecular fiber organization | negative regulation of cellular response to insulin stimulus | positive regulation of macromolecule biosynthetic process | actin filament-based process | response to endoplasmic reticulum stress | protein dephosphorylation | positive regulation of cellular component organization | cell motility | regulation of neurogenesis | immune response-regulating signaling pathway | regulation of endoplasmic reticulum unfolded protein response | positive regulation of apoptotic process | positive regulation of cap-dependent translational initiation | regulation of cell development | regulation of localization | protein kinase regulator activity | regulation of programmed cell death | actin cytoskeleton organization | establishment of localization | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | negative regulation of cellular process | negative regulation of kinase activity | positive regulation of developmental process | negative regulation of RNA biosynthetic process | positive regulation of lymphocyte activation | cell differentiation | immune response-activating cell surface receptor signaling pathway | signal complex assembly | T cell receptor signaling pathway | positive regulation of intrinsic apoptotic signaling pathway | nervous system development | negative regulation of protein phosphorylation | neurogenesis | positive regulation of cell adhesion | regulation of organelle organization | regulation of actin polymerization or depolymerization | generation of neurons | positive regulation of cellular biosynthetic process | cellular process | positive regulation of actin filament polymerization | Fc-gamma receptor signaling pathway involved in phagocytosis | regulation of cell motility | localization | negative regulation of signaling | negative regulation of peptidyl-serine phosphorylation | kinase regulator activity | protein kinase inhibitor activity | negative regulation of nucleic acid-templated transcription | negative regulation of response to endoplasmic reticulum stress | positive regulation of nitrogen compound metabolic process | regulation of neuron projection development | negative regulation of cellular metabolic process | regulation of cell differentiation | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of apoptotic process | regulation of metabolic process | negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation | regulation of protein complex assembly | positive regulation of translation | positive regulation of cellular protein metabolic process | ephrin receptor signaling pathway | cellular component organization | T cell activation | regulation of actin filament length | regulation of translational initiation | response to stimulus | enzyme inhibitor activity | lamellipodium assembly | positive regulation of translation in response to endoplasmic reticulum stress | positive regulation of immune system process | positive regulation of protein metabolic process | response to stress | negative regulation of protein kinase activity | regulation of response to endoplasmic reticulum stress | positive regulation of lymphocyte proliferation | posttranscriptional regulation of gene expression | regulation of cell proliferation | positive regulation of cell-cell adhesion | supramolecular fiber organization | positive regulation of cell activation | positive regulation of T cell activation | immune response-activating signal transduction | negative regulation of endoplasmic reticulum unfolded protein response | negative regulation of metabolic process | regulation of cellular component size | positive regulation of RNA biosynthetic process | cellular component assembly | protein modification process | regulation of cell adhesion | regulation of PERK-mediated unfolded protein response | macromolecule modification | molecular function regulator | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | locomotion | signaling adaptor activity | positive regulation of mononuclear cell proliferation | response to external biotic stimulus | system development | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | negative regulation of phosphate metabolic process | positive regulation of neuron projection development | regulation of actin cytoskeleton organization | multicellular organism development | negative regulation of catalytic activity | cell migration | phosphorus metabolic process | regulation of actin filament organization | actin filament organization | negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress | regulation of catalytic activity | regulation of phosphorylation | regulation of intrinsic apoptotic signaling pathway | Fc-gamma receptor signaling pathway | regulation of T cell activation | regulation of neuron differentiation | regulation of gene expression | cellular response to stress | cell projection assembly | positive regulation of cellular metabolic process | regulation of lymphocyte activation | regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | regulation of nitrogen compound metabolic process | regulation of cell migration | enzyme linked receptor protein signaling pathway | negative regulation of insulin receptor signaling pathway | positive regulation of cell projection organization | positive regulation of intracellular signal transduction | positive regulation of protein complex assembly | vesicle-mediated transport | regulation of cellular component movement | regulation of transcription by RNA polymerase II | positive regulation of cell differentiation | negative regulation of PERK-mediated unfolded protein response | regulation of cellular protein metabolic process | positive regulation of T cell proliferation | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis | cellular protein-containing complex assembly | regulation of apoptotic signaling pathway | positive regulation of cap-independent translational initiation | phosphate-containing compound metabolic process | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of actin filament polymerization | positive regulation of cytoskeleton organization | regulation of protein metabolic process | positive regulation of signal transduction | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of locomotion | regulation of RNA metabolic process | positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | lymphocyte activation | positive regulation of cytoplasmic translational initiation | positive regulation of translational initiation | lamellipodium organization | protein-containing complex assembly | activation of immune response | protein metabolic process | kinase inhibitor activity | regulation of kinase activity | import into cell | regulation of intracellular signal transduction | substrate-dependent cell migration | anatomical structure development | cell surface receptor signaling pathway | positive regulation of neurogenesis | cell projection organization | metabolic process | positive regulation of cell development | regulation of DNA-templated transcription in response to stress | positive regulation of supramolecular fiber organization | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | negative regulation of transcription, DNA-templated | endocytosis | positive regulation of cell death | positive regulation of cellular component biogenesis | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | regulation of insulin receptor signaling pathway | negative regulation of cellular protein metabolic process | regulation of cell activation | positive regulation of programmed cell death | negative regulation of transcription from RNA polymerase II promoter in response to stress | regulation of cellular response to insulin stimulus | regulation of phosphate metabolic process | cytoskeleton organization | SH3/SH2 adaptor activity | antigen receptor-mediated signaling pathway | positive regulation of cytoplasmic translation | regulation of cytoplasmic translation | cell activation | peptidyl-serine dephosphorylation | regulation of peptidyl-serine phosphorylation | negative regulation of protein metabolic process | positive regulation of translation in response to stress | regulation of cell communication | dephosphorylation | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | regulation of T cell proliferation | cellular protein metabolic process | enzyme regulator activity | regulation of transcription from RNA polymerase II promoter in response to stress | regulation of translation in response to stress | response to biotic stimulus | regulation of nervous system development | regulation of developmental process | regulation of translation in response to endoplasmic reticulum stress | developmental process | organelle organization | Fc receptor signaling pathway | cellular protein modification process | vascular endothelial growth factor receptor signaling pathway | Fc receptor mediated stimulatory signaling pathway | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | regulation of cell-cell adhesion | positive regulation of protein polymerization | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | regulation of actin filament-based process | positive regulation of neuron differentiation | regulation of cell projection organization | immune system process | cellular metabolic process | regulation of cell death | regulation of translation | negative regulation of cell death | phagocytosis | positive regulation of leukocyte cell-cell adhesion | regulation of cellular component organization | positive regulation of apoptotic signaling pathway | regulation of cytoskeleton organization | response to other organism | substrate-dependent cell migration, cell extension | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | positive regulation of response to endoplasmic reticulum stress | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | catalytic complex | organelle membrane | cell | cytoplasm | intracellular organelle | ribosome | endoplasmic reticulum | cell-cell junction | protein-containing complex | endomembrane system | plasma membrane | ribonucleoprotein complex | vesicle | protein phosphatase type 1 complex | protein serine/threonine phosphatase complex | membrane-bounded organelle | nucleus | organelle | vesicle membrane | cell periphery | cytosol | intracellular | cell junction | membrane
