Correlation Engine 2.0
Clear Search sequence regions
Bookmark Forward

QuickView for Oxycodone (compound)

Name: Oxycodone
PubChem Compound ID: 11518351
Description: A semisynthetic derivative of CODEINE.
Molecular formula: C18H21NO4
Molecular weight: 315.364 g/mol
Name: Oxycodone
Name (isomeric): DB00497
Drug Type: small molecule
Description: A semisynthetic derivative of CODEINE.
Dihydrone; Oxycodone Hcl; Oxicodona [INN-Spanish]; Oxycodone Hydrochloride; Oxycodonum [INN-Latin]; Dihydrohydroxycondeinone; Dihydrohydroxycodeinone; PTI-821
Brand: Oxanest, OxyNorm, Pancodine, Eucodal, Endodan, Dinarkon, Tecodin, Eucodalum, Dihydroxycodeinone, Oxycon, Combunox, Oxycodeinone, Oxicon, Oxicone, Tekodin, Remoxy, Percolone, Roxicodone, Eukodal, OxyFAST, Diphydrone, OxyIR, Eutagen, Percobarb, Eubine, Oxycontin, Oxikon, Thecodine, Supeudol, Supendol, Thekodin, Endocet, Percodan, Oxycodon, Endone
Brand name mixture:
Roxiprin(Aspirin + Oxycodone Hydrochloride), Percodan(Aspirin + Oxycodone Hydrochloride), Combunox(Ibuprofen + Oxycodone Hydrochloride), Tylox(Acetaminophen + Oxycodone Hydrochloride), Endodan(Aspirin + Oxycodone Hydrochloride), Roxicet(Acetaminophen + Oxycodone Hydrochloride), Rivacocet(Acetaminophen + Oxycodone Hydrochloride), Percocet(Acetami...
show more »
Category: Narcotics, Antitussives, Opiate Agonists, Analgesics, Opioid
CAS number: 76-42-6
Indication: For the treatment of diarrhoea, pulmonary oedema and for the relief of moderate to moderately severe pain.
Pharmacology: Oxycodone, a semisynthetic opiate agonist derived from the opioid alkaloid, thebaine, is similar to other phenanthrene derivatives such as hydrocodone and morphine. Oxycodone is available in combination with aspirin or acetaminophen to control pain and restless leg and Tourette syndromes.
Mechanism of Action:
Oxycodone acts as a weak agonist at mu, kappa, and delta opioid receptors within the central nervous system (CNS). Oxycodone primarily affects mu-type opioid receptors, which are coupled with G-protein receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Binding o...
show more »
Absorption: Well absorbed with an oral bioavailability of 60% to 87%
Protein binding: 45%
Biotransformation: Hepatic
Route of elimination: Oxycodone and its metabolites are excreted primarily via the kidney.
Half Life: 4.5 hours
Clearance: 0.8 L/min [adults]
Toxicity: Symptoms of overdose include respiratory depression, somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, constricted pupils, bradycardia, hypotension, and death.
Affected organisms: Humans and other mammals
Food interaction:
Take without regard to meals. Avoid alcohol.
Drug interaction:
TriprolidineThe CNS depressants, Triprolidine and Oxycodone, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
CimetidineCimetidine, a moderate CYP3A4 inhibitor, may decrease the metabolism of oxycodone. Monitor for changes in the therapeutic and adverse effects of oxycodone if cimetidine is initiated, discontinued or dose changed.
FluvoxamineIncreased risk of serotonin syndrome
FluoxetineIncreased risk of serotonin syndrome
CitalopramIncreased risk of serotonin syndrome
show more »