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QuickView for PDPN;jsessionid=1655030F9D60151804E014EA5E2501F9 (gene)


Gene Symbol:
PDPN Homo sapiens Homo sapiens
Full name:
podoplanin
Synonyms:
AGGRUS, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A, T1A-2, T1A2, TI1A, podoplanin, PA2.26 antigen, T1-alpha, glycoprotein 36, glycoprotein, 36-KD, hT1alpha-1, hT1alpha-2, lung type I cell membrane associated glycoprotein, lung type-I cell membrane-associated glycoprotein (T1A-2)
Genomic Location:
Chr 1: 13782839-13817039
Description:
This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has n...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Canis lupus familiaris Pan troglodytes Bos taurus Gallus gallus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 1
1p36.21





GO Molecular Function

cytokine binding | organic anion transmembrane transporter activity | anion transmembrane transporter activity | dicarboxylic acid transmembrane transporter activity | passive transmembrane transporter activity | water transmembrane transporter activity | transmembrane transporter activity | signaling receptor binding | organic acid transmembrane transporter activity | chemokine binding | chaperone binding | transporter activity | ion transmembrane transporter activity | drug transmembrane transporter activity | carboxylic acid transmembrane transporter activity | protein binding | water channel activity | amino acid transmembrane transporter activity | folic acid transmembrane transporter activity | channel activity | vitamin transmembrane transporter activity | substrate-specific channel activity

GO Biological Process

cell morphogenesis | lymphatic endothelial cell fate commitment | positive regulation of locomotion | actin filament-based process | positive regulation of cellular component organization | cell motility | regulation of cell morphogenesis | intracellular signal transduction | regulation of cell development | regulation of localization | morphogenesis of an epithelium | regulation of programmed cell death | organic anion transmembrane transporter activity | establishment of localization | regulation of cell shape | anion transmembrane transporter activity | negative regulation of cellular process | positive regulation of developmental process | cell differentiation | endothelial cell differentiation | respiratory tube development | fluid transport | response to drug | regulation of extracellular matrix organization | positive regulation of cell adhesion | positive regulation of cellular component movement | cellular process | dicarboxylic acid transmembrane transporter activity | regulation of cell motility | localization | passive transmembrane transporter activity | positive regulation of blood coagulation | positive regulation of epithelial to mesenchymal transition | regulation of platelet aggregation | dicarboxylic acid transport | anion transport | immune system development | positive regulation of extracellular matrix disassembly | hemostasis | negative regulation of apoptotic process | lymphangiogenesis | water transmembrane transporter activity | folic acid transport | tissue development | regulation of cell differentiation | actin filament-based movement | regulation of platelet activation | regulation of cellular process | regulation of apoptotic process | transmembrane transporter activity | positive regulation of extracellular matrix organization | small GTPase mediated signal transduction | epithelium development | cellular component organization | actin-mediated cell contraction | lymph vessel morphogenesis | response to stimulus | vasculature development | wound healing, spreading of cells | regulation of extracellular matrix disassembly | respiratory system development | response to stress | regulation of cell proliferation | positive regulation of cell-cell adhesion | organic acid transmembrane transporter activity | positive regulation of cell activation | cardiovascular system development | regulation of wound healing | regulation of cell adhesion | water transport | carboxylic acid transmembrane transport | epiboly | blood coagulation | locomotion | epithelial cell fate commitment | system development | positive regulation of response to wounding | endothelium development | multicellular organism development | cell migration | vitamin transport | lymph vessel development | ion transmembrane transport | positive regulation of platelet aggregation | wound healing | platelet activation | organic substance transport | regulation of blood coagulation | regulation of cell migration | regulation of cell-substrate adhesion | vitamin transmembrane transport | regulation of cellular component movement | organic acid transport | morphogenesis of an epithelial sheet | ion transmembrane transporter activity | positive regulation of cell differentiation | positive regulation of cell migration | organic anion transport | cell communication | positive regulation of platelet activation | drug transmembrane transporter activity | carboxylic acid transmembrane transporter activity | regulation of locomotion | coagulation | amino acid transport | lymph node development | regulation of cell morphogenesis involved in differentiation | water channel activity | regulation of homotypic cell-cell adhesion | tissue morphogenesis | Rho protein signal transduction | response to wounding | amino acid transmembrane transport | anion transmembrane transport | anatomical structure development | organic acid transmembrane transport | lymphatic endothelial cell differentiation | cofactor transport | cell projection organization | cell fate commitment | regulation of body fluid levels | negative regulation of programmed cell death | positive regulation of coagulation | amide transport | animal organ development | regulation of cell activation | amino acid transmembrane transporter activity | positive regulation of wound healing | folic acid transmembrane transporter activity | regulation of myofibroblast contraction | cell activation | lung development | drug transport | anatomical structure formation involved in morphogenesis | regulation of response to wounding | transmembrane transport | signaling | invadopodium organization | drug transmembrane transport | carboxylic acid transport | anatomical structure morphogenesis | channel activity | positive regulation of homotypic cell-cell adhesion | regulation of developmental process | developmental process | tube development | negative regulation of cell proliferation | regulation of cell-cell adhesion | Ras protein signal transduction | regulation of lamellipodium morphogenesis | epithelial cell differentiation | regulation of epithelial to mesenchymal transition | vitamin transmembrane transporter activity | regulation of actin filament-based process | ion transport | regulation of cell projection organization | immune system process | hematopoietic or lymphoid organ development | regulation of cell death | positive regulation of cell motility | regulation of substrate adhesion-dependent cell spreading | negative regulation of cell death | circulatory system development | substrate-specific channel activity | regulation of cellular component organization | signal transduction | multicellular organismal process

GO Cellular Component

leading edge of lamellipodium | integral component of membrane | apical plasma membrane | ruffle | cell projection membrane | cytoplasmic vesicle | actin-based cell projection | cell | intrinsic component of membrane | ruffle membrane | lamellipodium | cytoplasm | intracellular organelle | membrane microdomain | leading edge membrane | apical part of cell | cell projection | tetraspanin-enriched microdomain | plasma membrane | cell leading edge | membrane raft | vesicle | filopodium membrane | integral component of plasma membrane | microvillus | membrane-bounded organelle | filopodium | organelle | cell periphery | microvillus membrane | basolateral plasma membrane | invadopodium | cytosol | intracellular vesicle | intracellular | cell junction | membrane | lamellipodium membrane | intrinsic component of plasma membrane