QuickView for PFKFB1;jsessionid=3B47A6AC7774A3BDAA3102D8D5F3AD5D (gene)

Gene Symbol:

PFKFB1 Homo sapiens

Full name:

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

Synonyms:

F6PK, HL2K, PFRX, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1, 6PF-2-K/Fru-2,6-P2ASE liver isozyme, 6PF-2-K/Fru-2,6-P2ase 1, PFK/FBPase 1, fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase

Genomic Location:

Chr X: 54976315-55037236

Description:

This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of t...

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This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

OCT1_B ,  TGANNYRGCA_TCF11MAFG_01 ,  OCT1_01 ,  GATA3_01 ,  GATA_Q6 ,  YATGNWAAT_OCT_C ,  OCT_Q6 ,  SMAD3_Q6 ,  GATAAGR_GATA_C ,  OCT1_Q5_01 ,  OCT_C ,  HNF4_DR1_Q3 ,  WTGAAAT_UNKNOWN ,  HNF4_01 ,  OCT1_Q6 ,  CEBP_01 ,  GATA6_01 ,  MGGAAGTG_GABP_B ,  GATA1_02 ,  OCT1_02 ,  AACTTT_UNKNOWN ,  USF_02 ,  GGGTGGRR_PAX4_03

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Cytogenetic Map:

Xp11.21

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