QuickView for PTPRM (gene)

Gene Symbol:

PTPRM Homo sapiens

Full name:

protein tyrosine phosphatase, receptor type M

Synonyms:

PTPRL1, R-PTP-MU, RPTPM, RPTPU, hR-PTPu, receptor-type tyrosine-protein phosphatase mu, protein tyrosine phosphatase mu, protein tyrosine phosphatase, receptor type, mu polypeptide

Genomic Location:

Chr 18: 7557314-8396859

Description:

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two ...

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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGCC_MIR34A_MIR34C_MIR449 ,  TTANTCA_UNKNOWN ,  CTTTGCA_MIR527 ,  TTGCACT_MIR130A_MIR301_MIR130B ,  TGTATGA_MIR4853P ,  TGCACTG_MIR148A_MIR152_MIR148B ,  TTGTTT_FOXO4_01 ,  ATGAAGG_MIR205

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-205 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-365 ,  Predicted Gene Targets for miR-485-3p

Cytogenetic Map:

18p11.23

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