QuickView for PdL1 (gene)

Gene Symbol:

Cd274 Mus musculus

Full name:

CD274 antigen

Synonyms:

A530045L16Rik, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1, programmed cell death 1 ligand 1, B7 homolog 1, PDCD1 ligand 1

Genomic Location:

Chr 19: 29441945-29462585

Description:

The protein encoded by this gene is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor i...

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The protein encoded by this gene is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Mice deficient for this gene display a variety of phenotypes including decreased allogeneic fetal survival rates and severe experimental autoimmune encephalomyelitis.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AACTTT_UNKNOWN ,  NFAT_Q6 ,  IPF1_Q4 ,  STAT5A_03 ,  STAT6_01 ,  STAT6_02 ,  PTF1BETA_Q6 ,  ELF1_Q6 ,  PAX_Q6 ,  TTCYRGAA_UNKNOWN ,  CTTTGA_LEF1_Q2

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