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QuickView for Phenindamine (compound)

Summary
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PubChem

PubChem Compound 11290

PubChem Compound 11290

Name:	phenindamine
PubChem Compound ID:	11290
Molecular formula:	C₂₃H₂₅NO₆
Molecular weight:	411.448 g/mol
Synonyms:	Pernovine; Thephorin; 1H-Indeno(2,1-c)pyridine, 2,3,4,9-tetrahydro-2-methyl-9-phenyl-, (R-(R,R)-2,3-dihydroxybutanedioate (1:1); Phenindamine hydrogen tartrate; PV Tussin Tablet; 569-59-5; D02148; PV Tussin Syrup; Phenindamine tartrate [USAN]; 2,3,4,9-Tetrahydro-2-methyl-9-phenyl-1H-indeno(2,1-c)pyridine L-(+)-tartrate (1:1). show more » Pernovine; Thephorin; 1H-Indeno(2,1-c)pyridine, 2,3,4,9-tetrahydro-2-methyl-9-phenyl-, (R-(R,R)-2,3-dihydroxybutanedioate (1:1); Phenindamine hydrogen tartrate; PV Tussin Tablet; 569-59-5; D02148; PV Tussin Syrup; Phenindamine tartrate [USAN]; 2,3,4,9-Tetrahydro-2-methyl-9-phenyl-1H-indeno(2,1-c)pyridine L-(+)-tartrate (1:1); NSC 91526; Nolahist (TN); Phenindamine tartrate (USAN); 2-Methyl-9-phenyl-2,3,4,9-tetrahydro-1H-indeno(2,1-c)pyridine tartrate; EINECS 209-320-7; Phenindamine bitartrate; Nolahist; Phenindamine tartrate; 82-88-2; 1H-Indeno(2,1-c)pyridine, 2,3,4,9-tetrahydro-2-methyl-9-phenyl-, tartrate (1:1) (VAN) (8CI); 1H-INDENO(2,1-c)PYRIDINE, 2,3,4,9-TETRAHYDRO-2-METHYL-9-PHENYL-, TARTRATE (1:1); Plegine show less «

DrugBank

Identification

Name:	phenindamine
Name (isomeric):	DB01619
Drug Type:	small molecule
Synonyms:	Phenindaminum [inn-latin]; Phenindiamine; Fenindamina [inn-spanish]
Brand:	Nolahist, Thephorin
Brand name mixture:	Amilon()
Category:	Antihistamines, Histamine H1 Antagonists
CAS number:	82-88-2

Pharmacology

Indication:	Used to treat sneezing, runny nose, itching, watery eyes, hives, rashes, itching, and other symptoms of allergies and the common cold.
Pharmacology:	Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Allergies are caused by an excessive type 1 hypersensitivity response of the body to allergens, mediated by inappropriate histamine signalling. By inhibiting the binding of histamine, antihistamines decrease the normal hista... show more » Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Allergies are caused by an excessive type 1 hypersensitivity response of the body to allergens, mediated by inappropriate histamine signalling. By inhibiting the binding of histamine, antihistamines decrease the normal histamine response from cells, consequently decreasing allergic symptoms. show less «
Mechanism of Action:	Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving hist... show more » Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release. show less «
Toxicity:	Symptoms of a phenindamine overdose include extreme sleepiness, confusion, weakness, ringing in the ears, blurred vision, large pupils, dry mouth, flushing, fever, shaking, insomnia, hallucinations, and possibly seizures.
Affected organisms:	Humans and other mammals

Interactions

Food interaction:

Avoid alcohol.

Take with food to reduce irritation.

Drug interaction:

Trospium	Trospium and Phenindamine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Tacrine	The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Phenindamine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
Triprolidine	Triprolidine and Phenindamine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
Donepezil	Possible antagonism of action
Galantamine	Possible antagonism of action

Targets

Histamine H1 receptor