QuickView for RANGRF;jsessionid=070A5958F158B6579726E4495B5E4D12 (gene)
- Gene Symbol:
- RANGRF
Homo sapiens - Full name:
- RAN guanine nucleotide release factor
- Synonyms:
- HSPC165, HSPC236, MOG1, RANGNRF, ran guanine nucleotide release factor, MOG1 homolog, ran-binding protein MOG1
- Genomic Location:
- Chr 17: 8132714-8134130
- Description:
-
This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript variants.
- Orthologs:
- Mus musculus , Rattus norvegicus , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
17p13.1
GO Molecular Function
guanyl-nucleotide exchange factor activity | GTPase binding | channel regulator activity | enzyme binding | sodium channel regulator activity | protein transporter activity | Ras GTPase binding | molecular function regulator | ion channel binding | transporter activity | protein binding | Ras guanyl-nucleotide exchange factor activity | Ran GTPase binding | small GTPase binding | Ran guanyl-nucleotide exchange factor activity
GO Biological Process
regulation of supramolecular fiber organization | regulation of muscle system process | guanyl-nucleotide exchange factor activity | regulation of microtubule polymerization or depolymerization | regulation of sodium ion transmembrane transporter activity | regulation of cellular localization | intracellular signal transduction | regulation of localization | regulation of sodium ion transport | establishment of localization | Ran protein signal transduction | regulation of protein localization to membrane | regulation of organelle organization | intracellular transport | cellular process | channel regulator activity | localization | protein transport | regulation of sodium ion transmembrane transport | macromolecule localization | establishment of localization in cell | regulation of cellular process | sodium channel regulator activity | regulation of bundle of His cell action potential | regulation of protein complex assembly | small GTPase mediated signal transduction | protein transporter activity | response to stimulus | regulation of cellular protein localization | intracellular protein transport | positive regulation of cellular protein localization | regulation of blood circulation | regulation of cardiac muscle cell contraction | regulation of heart rate | cellular localization | molecular function regulator | regulation of membrane potential | regulation of muscle contraction | regulation of protein localization to cell surface | positive regulation of protein localization to plasma membrane | positive regulation of protein localization to cell surface | regulation of microtubule nucleation | organic substance transport | regulation of membrane depolarization | peptide transport | vesicle-mediated transport | regulation of cellular component movement | regulation of membrane depolarization during action potential | regulation of heart contraction | regulation of striated muscle contraction | cell communication | positive regulation of protein localization to membrane | regulation of cardiac muscle contraction | regulation of cardiac muscle cell action potential | homeostatic process | Golgi vesicle transport | regulation of microtubule-based process | regulation of microtubule polymerization | regulation of protein localization to plasma membrane | cellular protein localization | amide transport | chemical homeostasis | Ras guanyl-nucleotide exchange factor activity | regulation of membrane depolarization during cardiac muscle cell action potential | ion homeostasis | regulation of ion transmembrane transport | establishment of protein localization | regulation of action potential | regulation of cell communication | ER to Golgi vesicle-mediated transport | signaling | regulation of transmembrane transporter activity | protein localization | regulation of ion transmembrane transporter activity | cellular macromolecule localization | regulation of microtubule nucleation by Ran protein signal transduction | regulation of ion transport | regulation of cardiac conduction | regulation of transport | Ras protein signal transduction | regulation of actin filament-based process | regulation of protein localization | Ran guanyl-nucleotide exchange factor activity | protein exit from endoplasmic reticulum | regulation of microtubule cytoskeleton organization | regulation of cellular component organization | regulation of cytoskeleton organization | regulation of cardiac muscle cell action potential involved in regulation of contraction | signal transduction | regulation of signaling
GO Cellular Component
intercalated disc | intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | endoplasmic reticulum | membrane microdomain | cell-cell junction | cell-cell contact zone | endomembrane system | nucleoplasm | plasma membrane | membrane raft | perinuclear region of cytoplasm | membrane-bounded organelle | nucleus | organelle | cell periphery | membrane-enclosed lumen | plasma membrane raft | rough endoplasmic reticulum | cytosol | intracellular | cell junction | caveola | membrane
