QuickView for RELA (gene)

Gene Symbol:

RELA Homo sapiens

Full name:

RELA proto-oncogene, NF-kB subunit

Synonyms:

NFKB3, p65, transcription factor p65, NF-kappa-B p65delta3, NF-kappa-B transcription factor p65, nuclear factor NF-kappa-B p65 subunit, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, v-rel avian reticuloendotheliosis viral oncogene homolog A, v-rel reticuloendotheliosis viral oncogene homolog A

Genomic Location:

Chr 11: 65178393-65186951

Description:

NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RE...

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NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  AP1_C ,  TGANTCA_AP1_C ,  STAT1_02 ,  TTANTCA_UNKNOWN ,  HEN1_01 ,  NGFIC_01 ,  EVI1_04 ,  STAT6_01 ,  STAT1_03 ,  EGR2_01 ,  TGAYRTCA_ATF3_Q6 ,  GTGACGY_E4F1_Q6 ,  SP1_Q4_01 ,  YY1_01 ,  TGCGCANK_UNKNOWN ,  GGGCGGR_SP1_Q6 ,  GCM_Q2 ,  SP1_Q6 ,  YCATTAA_UNKNOWN ,  HMGIY_Q6 ,  MTF1_Q4 ,  CEBP_C ,  HEN1_02 ,  STAT1_01 ,  CAGCTG_AP4_Q5 ,  SP1_Q6_01 ,  TGACATY_UNKNOWN ,  DR4_Q2 ,  AP1_Q4_01 ,  ELF1_Q6 ,  SP1_Q2_01 ,  LBP1_Q6

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miRNA binding sites
(Source: miRecords):

hsa-miR-124 Targeted Genes ,  hsa-miR-373 Targeted Genes

Cytogenetic Map:

11q13.1

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