QuickView for RGS4 (gene)

Gene Symbol:

RGS4 Homo sapiens

Full name:

regulator of G protein signaling 4

Synonyms:

RGP4, SCZD9, regulator of G-protein signaling 4, schizophrenia disorder 9

Genomic Location:

Chr 1: 161305285-161313216

Description:

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator o...

View Full Description

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  CTCTATG_MIR368 ,  TACTTGA_MIR26A_MIR26B ,  AATGGAG_MIR136 ,  TATAAA_TATA_01 ,  ATGCTGC_MIR103_MIR107 ,  TATA_01 ,  ERR1_Q2 ,  SF1_Q6

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-136 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-31

Cytogenetic Map:

1q23.3

search → result