QuickView for ROCK2;jsessionid=18AEAE53A740BB6FB42BEEB060A03A17 (gene)

Gene Symbol:

ROCK2 Homo sapiens

Full name:

Rho associated coiled-coil containing protein kinase 2

Synonyms:

ROCK-II, rho-associated protein kinase 2, p164 ROCK-2, rho-associated, coiled-coil-containing protein kinase II

Genomic Location:

Chr 2: 11239229-11402162

Description:

The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.

The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CTTGTAT_MIR381 ,  AP1_C ,  TFIIA_Q6 ,  TGANTCA_AP1_C ,  AAGCCAT_MIR135A_MIR135B ,  MYOGNF1_01 ,  SRF_Q6 ,  CTATGCA_MIR153 ,  VDR_Q6 ,  AP1_Q6 ,  CTTTGA_LEF1_Q2 ,  GGGAGGRR_MAZ_Q6 ,  AP1_Q6_01 ,  CACCAGC_MIR138 ,  AP1FJ_Q2 ,  TGCCTTA_MIR124A ,  SRF_Q4 ,  AP1_Q4 ,  TCTATGA_MIR376A_MIR376B ,  WGGAATGY_TEF1_Q6 ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  AP1_Q2 ,  AACTTT_UNKNOWN ,  PPAR_DR1_Q2 ,  ER_Q6 ,  SRF_C ,  ACACTAC_MIR1423P

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-138 ,  Predicted Gene Targets for miR-142-3p ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-376 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u

Cytogenetic Map:

2p25.1

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