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QuickView for RORB;jsessionid=97FC937E6DA9AF7173E2C055DDCFA6B7 (gene)


Gene Symbol:
RORB Homo sapiens Homo sapiens
Full name:
RAR related orphan receptor B
Synonyms:
NR1F2, ROR-BETA, RZR-BETA, RZRB, bA133M9.1, nuclear receptor ROR-beta, RAR-related orphan receptor beta, nuclear receptor RZR-beta, nuclear receptor subfamily 1 group F member 2, retinoic acid-binding receptor beta, retinoid-related orphan receptor beta
Genomic Location:
Chr 9: 76302072-76491937
Description:
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
CACTGTG_MIR128A_MIR128B IRF1_01 RTAAACA_FREAC2_01 HNF1_01 TTANTCA_UNKNOWN TCANNTGAY_SREBP1_01 FOXJ2_02 GATA_C CCTGAGT_MIR510 EVI1_04
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 9
9q21.13


Transcripts Names
NM_006914
Protein Names
Q8WX73
Q58EY0



GO Molecular Function

sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | nuclear receptor activity | cation binding | transcription factor activity, direct ligand regulated sequence-specific DNA binding | transmembrane signaling receptor activity | proximal promoter sequence-specific DNA binding | nucleic acid binding | G-protein coupled receptor activity | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | steroid hormone receptor activity | RNA polymerase II regulatory region DNA binding | DNA binding | signaling receptor activity | sequence-specific double-stranded DNA binding | ion binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | zinc ion binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | melatonin receptor activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | transition metal ion binding | metal ion binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | DNA-templated transcription, initiation | positive regulation of macromolecule biosynthetic process | eye development | response to hormone | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of RNA biosynthetic process | cell differentiation | nervous system development | neurogenesis | generation of neurons | hormone-mediated signaling pathway | neural retina development | positive regulation of cellular biosynthetic process | cellular process | nuclear receptor activity | neuron development | transcription factor activity, direct ligand regulated sequence-specific DNA binding | negative regulation of nucleic acid-templated transcription | positive regulation of nitrogen compound metabolic process | retinal rod cell development | negative regulation of cellular metabolic process | regulation of cell differentiation | cellular response to retinoic acid | regulation of cellular process | regulation of osteoblast differentiation | cellular response to lipid | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | retinal cone cell differentiation | G-protein coupled receptor activity | response to stimulus | cellular nitrogen compound biosynthetic process | rhythmic process | cellular nitrogen compound metabolic process | cellular response to organic cyclic compound | G-protein coupled receptor signaling pathway | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | steroid hormone receptor activity | steroid hormone mediated signaling pathway | cellular biosynthetic process | eye photoreceptor cell differentiation | regulation of nucleic acid-templated transcription | negative regulation of osteoblast differentiation | cellular response to hormone stimulus | system development | nitrogen compound metabolic process | multicellular organism development | retina morphogenesis in camera-type eye | regulation of ossification | regulation of gene expression | response to lipid | nervous system process | positive regulation of cellular metabolic process | retinal cone cell development | animal organ morphogenesis | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | biosynthetic process | aromatic compound biosynthetic process | sensory organ development | cell communication | regulation of cellular metabolic process | eye morphogenesis | regulation of RNA metabolic process | eye photoreceptor cell development | response to retinoic acid | neuron differentiation | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | response to organic substance | retina development in camera-type eye | negative regulation of ossification | anatomical structure development | melatonin receptor activity | metabolic process | visual perception | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | sensory perception of light stimulus | gene expression | cellular response to steroid hormone stimulus | transcription initiation from RNA polymerase II promoter | transcription, DNA-templated | intracellular receptor signaling pathway | camera-type eye development | sensory perception | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | cell development | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | camera-type eye morphogenesis | amacrine cell differentiation | regulation of circadian rhythm | regulation of developmental process | developmental process | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | photoreceptor cell development | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | cellular metabolic process | photoreceptor cell differentiation | cellular response to organic substance | response to steroid hormone | camera-type eye photoreceptor cell differentiation | negative regulation of cell differentiation | signal transduction | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | intracellular organelle | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular