QuickView for SAP97 (gene)
- Gene Symbol:
- DLG1
Homo sapiens - Full name:
- discs large MAGUK scaffold protein 1
- Synonyms:
- DLGH1, SAP-97, SAP97, dJ1061C18.1.1, hdlg, disks large homolog 1, discs large homolog 1, scribble cell polarity complex component, discs, large homolog 1 transcript variant 6-v1, discs, large homolog 1 transcript variant 6-v2, presynaptic protein SAP97, synapse-associated protein 97
- Genomic Location:
- Chr 3: 198253828-198509844
- Description:
-
This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, ...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
3q29
GO Molecular Function
structural molecule activity | kinase binding | nucleoside monophosphate kinase activity | channel regulator activity | cadherin binding | passive transmembrane transporter activity | protein kinase binding | enzyme binding | transmembrane transporter activity | ligand-gated ion channel activity | phosphatase activity | ion gated channel activity | signaling receptor binding | hydrolase activity | molecular function regulator | catalytic activity | ion channel binding | protein domain specific binding | cytoskeletal protein binding | phosphoprotein phosphatase activity | transporter activity | mitogen-activated protein kinase kinase binding | hydrolase activity, acting on ester bonds | ion transmembrane transporter activity | potassium channel regulator activity | nucleobase-containing compound kinase activity | cell adhesion molecule binding | protein binding | transferase activity, transferring phosphorus-containing groups | phosphoric ester hydrolase activity | protein-containing complex scaffold activity | phosphotransferase activity, phosphate group as acceptor | transferase activity | guanylate kinase activity | channel activity | kinase activity | phosphatase binding | ion channel activity | protein C-terminus binding | substrate-specific channel activity | glutamate receptor binding | ionotropic glutamate receptor binding | L27 domain binding
GO Biological Process
negative regulation of leukocyte activation | regulation of ERK1 and ERK2 cascade | negative regulation of phosphorylation | regulation of supramolecular fiber organization | purine ribonucleotide metabolic process | adaptive immune response | regulation of muscle system process | regulation of ventricular cardiac muscle cell membrane repolarization | negative regulation of MAPK cascade | negative regulation of immune system process | hard palate development | actin filament-based process | protein dephosphorylation | GMP metabolic process | positive regulation of cellular component organization | regulation of cell morphogenesis | developmental process involved in reproduction | protein localization to cell periphery | regulation of cellular localization | muscle tissue development | regulation of localization | cellular protein-containing complex localization | morphogenesis of an epithelium | regulation of sodium ion transport | nucleoside monophosphate kinase activity | eye development | actin cytoskeleton organization | establishment of localization | regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization | regulation of immune system process | regulation of cell shape | negative regulation of cellular process | negative regulation of leukocyte cell-cell adhesion | negative regulation of RNA biosynthetic process | microtubule cytoskeleton organization | regulation of protein localization to membrane | negative regulation of protein phosphorylation | positive regulation of phosphate metabolic process | regulation of organelle organization | regulation of actin polymerization or depolymerization | establishment or maintenance of apical/basal cell polarity | membrane organization | regulation of ventricular cardiac muscle cell action potential | microtubule-based process | negative regulation of stress-activated protein kinase signaling cascade | cellular process | positive regulation of actin filament polymerization | channel regulator activity | establishment of organelle localization | localization | epithelial tube morphogenesis | passive transmembrane transporter activity | regulation of sodium ion transmembrane transport | nucleotide metabolic process | negative regulation of signaling | chemical synaptic transmission | reproductive system development | ribose phosphate metabolic process | negative regulation of nucleic acid-templated transcription | renal tubule morphogenesis | positive regulation of protein kinase activity | macromolecule localization | branching involved in ureteric bud morphogenesis | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | ribonucleotide metabolic process | negative regulation of T cell proliferation | nucleoside monophosphate phosphorylation | endothelial cell proliferation | establishment of localization in cell | negative regulation of cellular metabolic process | tissue development | interspecies interaction between organisms | cell junction assembly | cell recognition | regulation of protein kinase B signaling | regulation of cellular process | leukocyte activation | regulation of metabolic process | regulation of protein complex assembly | organelle localization | cortical actin cytoskeleton organization | transmembrane transporter activity | negative regulation of mononuclear cell proliferation | regulation of potassium ion export across plasma membrane | negative regulation of p38MAPK cascade | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | ligand-gated ion channel activity | epithelium development | cellular aromatic compound metabolic process | smooth muscle contraction | cellular component organization | positive regulation of potassium ion transport | urogenital system development | T cell cytokine production | T cell activation | regulation of actin filament length | phosphatase activity | nephron tubule morphogenesis | muscle contraction | response to stimulus | ion gated channel activity | purine nucleotide metabolic process | regulation of cellular protein localization | positive regulation of protein metabolic process | negative regulation of cell adhesion | cortical microtubule organization | regulation of potassium ion import | negative regulation of lymphocyte activation | positive regulation of cellular protein localization | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | roof of mouth development | tube morphogenesis | regulation of blood circulation | regulation of cardiac muscle cell contraction | receptor clustering | supramolecular fiber organization | peristalsis | reproduction | cellular localization | embryonic skeletal system development | astral microtubule organization | cellular nitrogen compound metabolic process | negative regulation of metabolic process | regulation of cellular component size | cellular component assembly | protein modification process | membrane raft organization | regulation of cell adhesion | cellular biosynthetic process | purine nucleoside metabolic process | kidney development | embryo development | macromolecule modification | cell-cell signaling | negative regulation of ERK1 and ERK2 cascade | activation of protein kinase activity | GDP metabolic process | molecular function regulator | nucleotide biosynthetic process | regulation of nucleic acid-templated transcription | regulation of potassium ion transmembrane transport | regulation of membrane potential | regulation of cellular response to stress | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | positive regulation of organelle organization | ureteric bud development | negative regulation of phosphate metabolic process | regulation of actin cytoskeleton organization | multicellular organism development | regulation of MAPK cascade | phosphorus metabolic process | regulation of actin filament organization | actin filament organization | leukocyte mediated immunity | regulation of muscle contraction | regulation of catalytic activity | regulation of phosphorylation | kidney morphogenesis | ion transmembrane transport | localization within membrane | regulation of T cell activation | protein localization to plasma membrane | positive regulation of protein localization to plasma membrane | regulation of gene expression | kidney epithelium development | protein localization to membrane | cell cycle | synaptic signaling | organophosphate metabolic process | nucleoside metabolic process | positive regulation of cellular metabolic process | cell-cell recognition | positive regulation of protein phosphorylation | regulation of lymphocyte activation | animal organ morphogenesis | phosphoprotein phosphatase activity | regulation of myelination | regulation of nitrogen compound metabolic process | negative regulation of T cell activation | small molecule metabolic process | regulation of membrane repolarization during cardiac muscle cell action potential | apical junction assembly | positive regulation of protein complex assembly | regulation of cellular component movement | regulation of transcription by RNA polymerase II | ion transmembrane transporter activity | bicellular tight junction assembly | nucleobase-containing small molecule metabolic process | cell proliferation | biosynthetic process | negative regulation of protein kinase B signaling | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | phosphorylation | mesonephric epithelium development | negative regulation of stress-activated MAPK cascade | potassium channel regulator activity | nucleobase-containing compound kinase activity | cytokine production involved in immune response | regulation of heart contraction | mesonephros development | establishment or maintenance of cell polarity | phosphate-containing compound metabolic process | sensory organ development | regulation of potassium ion transmembrane transporter activity | regulation of striated muscle contraction | receptor localization to synapse | negative regulation of cell-cell adhesion | chordate embryonic development | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of protein localization to membrane | regulation of actin filament polymerization | skeletal system morphogenesis | renal tubule development | centrosome localization | cytoplasmic microtubule organization | negative regulation of cell activation | T cell mediated immunity | protein-containing complex localization | regulation of cardiac muscle contraction | positive regulation of cytoskeleton organization | regulation of NIK/NF-kappaB signaling | regulation of cardiac muscle cell action potential | regulation of protein metabolic process | positive regulation of cell proliferation | regulation of protein phosphorylation | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | renal system development | positive regulation of transport | viral process | embryonic morphogenesis | regulation of mitotic cell cycle | nephron development | smooth muscle tissue development | lymphocyte activation | regulation of potassium ion transport | positive regulation of molecular function | secondary palate development | cytokine production | embryonic organ morphogenesis | ureteric bud morphogenesis | negative regulation of epithelial cell proliferation | protein metabolic process | positive regulation of protein modification process | tissue morphogenesis | branching morphogenesis of an epithelial tube | nucleoside diphosphate metabolic process | epithelial cell proliferation | regulation of kinase activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | mitotic cell cycle | embryonic skeletal system morphogenesis | metabolic process | positive regulation of supramolecular fiber organization | cell-cell junction assembly | regulation of protein localization to plasma membrane | negative regulation of leukocyte proliferation | regulation of RNA biosynthetic process | establishment or maintenance of epithelial cell apical/basal polarity | negative regulation of transcription, DNA-templated | embryonic organ development | microtubule organizing center localization | negative regulation of mitotic cell cycle | cellular protein localization | cell adhesion | immune response | nucleobase-containing compound metabolic process | positive regulation of cellular component biogenesis | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | nephron morphogenesis | animal organ development | positive regulation of ion transport | negative regulation of cellular protein metabolic process | regulation of cell activation | positive regulation of kinase activity | regulation of phosphate metabolic process | cytoskeleton organization | regulation of ion transmembrane transport | cell-cell adhesion | cell activation | guanylate kinase activity | morphogenesis of a branching epithelium | camera-type eye development | negative regulation of cell cycle | negative regulation of protein metabolic process | regulation of action potential | regulation of stress-activated MAPK cascade | regulation of cell communication | dephosphorylation | negative regulation of signal transduction | transmembrane transport | signaling | regulation of transcription, DNA-templated | regulation of T cell proliferation | regulation of transmembrane transporter activity | protein localization | regulation of epithelial cell proliferation | regulation of ion transmembrane transporter activity | positive regulation of phosphorylation | immunological synapse formation | cellular protein metabolic process | morphogenesis of a branching structure | anatomical structure morphogenesis | cellular macromolecule localization | channel activity | reproductive structure development | regulation of nervous system development | regulation of developmental process | regulation of ion transport | kinase activity | developmental process | organelle organization | cellular protein modification process | cortical cytoskeleton organization | negative regulation of transcription by RNA polymerase II | tube development | carbohydrate derivative metabolic process | regulation of transport | negative regulation of cell proliferation | regulation of cell-cell adhesion | positive regulation of protein polymerization | regulation of cation channel activity | heterocycle metabolic process | regulation of membrane repolarization during action potential | ion channel activity | positive regulation of metabolic process | regulation of actin filament-based process | ion transport | skeletal system development | negative regulation of lymphocyte proliferation | immune system process | mitotic cell cycle checkpoint | cellular metabolic process | establishment of centrosome localization | regulation of protein localization | cell cycle checkpoint | spindle organization | substrate-specific channel activity | nephron tubule development | regulation of membrane repolarization | regulation of cellular component organization | lens development in camera-type eye | regulation of cytoskeleton organization | muscle system process | regulation of signaling | regulation of p38MAPK cascade | mesonephric tubule development | amyloid precursor protein metabolic process | macromolecule metabolic process | multicellular organismal process | cell-cell junction organization | regulation of phosphorus metabolic process
GO Cellular Component
supramolecular fiber | occluding junction | intercalated disc | integral component of membrane | cytoplasmic side of plasma membrane | intracellular membrane-bounded organelle | sarcolemma | synapse | apical plasma membrane | neuron projection | immunological synapse | adherens junction | cell projection membrane | neuromuscular junction | postsynaptic specialization membrane | cell | cytoplasmic side of membrane | myelin sheath abaxonal region | plasma membrane protein complex | intrinsic component of membrane | synaptic membrane | microtubule | cytoplasm | intracellular organelle | receptor complex | endoplasmic reticulum | membrane microdomain | main axon | apical part of cell | MPP7-DLG1-LIN7 complex | cell-cell junction | cell-cell contact zone | Golgi apparatus | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | cell projection | postsynaptic membrane | endomembrane system | endoplasmic reticulum membrane | postsynapse | plasma membrane | lateral loop | postsynaptic density membrane | membrane raft | vesicle | perinuclear region of cytoplasm | postsynaptic density | extracellular exosome | microtubule cytoskeleton | asymmetric synapse | node of Ranvier | integral component of plasma membrane | extracellular region | membrane-bounded organelle | extracellular vesicle | apical junction complex | nucleus | organelle | postsynaptic specialization | extracellular space | cell periphery | bicellular tight junction | axon | basolateral plasma membrane | ionotropic glutamate receptor complex | transmembrane transporter complex | ion channel complex | cytosol | cytoskeleton | intracellular | cell junction | myelin sheath | lateral plasma membrane | membrane | supramolecular complex | intrinsic component of plasma membrane
