QuickView for SAV1 (gene)

Gene Symbol:

SAV1 Homo sapiens

Full name:

salvador family WW domain containing protein 1

Synonyms:

SAV, WW45, WWP4, protein salvador homolog 1, 1700040G09Rik, 45 kDa WW domain protein, WW domain-containing adaptor 45, hWW45, salvador homolog 1

Genomic Location:

Chr 14: 50170110-50204773

Description:

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This pr...

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WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

HOXA4_Q2 ,  AP3_Q6 ,  SMAD3_Q6 ,  TGCAAAC_MIR452 ,  NCX_01 ,  EN1_01 ,  CEBP_C ,  IK1_01 ,  AACTTT_UNKNOWN ,  RACTNNRTTTNC_UNKNOWN

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-452

Cytogenetic Map:

14q22.1

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