QuickView for SIAH1;jsessionid=CEB40C348C45423EDC9FD97E0F4A3375 (gene)
- Gene Symbol:
- SIAH1
Homo sapiens - Full name:
- siah E3 ubiquitin protein ligase 1
- Synonyms:
- SIAH1A, E3 ubiquitin-protein ligase SIAH1, RING-type E3 ubiquitin transferase SIAH1, seven in absentia homolog 1, siah-1a
- Genomic Location:
- Chr 16: 46951943-46976730
- Description:
-
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of t...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-129 , Predicted Gene Targets for miR-135 , Predicted Gene Targets for miR-15 , Predicted Gene Targets for miR-193 , Predicted Gene Targets for miR-141 , Predicted Gene Targets for miR-200b , Predicted Gene Targets for miR-205 , Predicted Gene Targets for miR-299 , Predicted Gene Targets for miR-30-3p , Predicted Gene Targets for miR-329
- Cytogenetic Map:
-
16q12.1
GO Molecular Function
cation binding | enzyme binding | catalytic activity | ubiquitin-like protein transferase activity | ubiquitin conjugating enzyme binding | identical protein binding | ubiquitin protein ligase activity | ion binding | protein binding | zinc ion binding | ubiquitin-protein transferase activity | ubiquitin-like protein conjugating enzyme binding | transferase activity | transition metal ion binding | ubiquitin-like protein ligase activity | metal ion binding | protein C-terminus binding
GO Biological Process
cell morphogenesis | neuron projection morphogenesis | negative regulation of netrin-activated signaling pathway | positive regulation of apoptotic process | proteolysis | regulation of programmed cell death | neuron death | negative regulation of cellular process | cell differentiation | male gamete generation | positive regulation of intrinsic apoptotic signaling pathway | nervous system development | cell part morphogenesis | neurogenesis | generation of neurons | cellular process | organic substance catabolic process | cell projection morphogenesis | proteolysis involved in cellular protein catabolic process | negative regulation of signaling | neuron development | multicellular organismal reproductive process | axon guidance | gamete generation | regulation of cellular process | regulation of apoptotic process | catabolic process | cellular component organization | response to stimulus | cell morphogenesis involved in neuron differentiation | neuron projection guidance | programmed cell death | protein destabilization | reproduction | cellular protein catabolic process | proteasomal protein catabolic process | protein modification process | macromolecule modification | locomotion | apoptotic process | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | regulation of protein stability | multicellular organism development | regulation of intrinsic apoptotic signaling pathway | axon development | cell cycle | protein catabolic process | protein modification by small protein conjugation | neuron apoptotic process | positive regulation of intracellular signal transduction | ubiquitin protein ligase activity | axonogenesis | regulation of apoptotic signaling pathway | cell morphogenesis involved in differentiation | positive regulation of signal transduction | proteasome-mediated ubiquitin-dependent protein catabolic process | protein polyubiquitination | neuron differentiation | multicellular organism reproduction | protein metabolic process | protein ubiquitination | regulation of intracellular signal transduction | cellular macromolecule catabolic process | anatomical structure development | cell projection organization | metabolic process | ubiquitin-protein transferase activity | positive regulation of cell death | neuron projection development | organic substance metabolic process | cell death | positive regulation of programmed cell death | protein modification by small protein conjugation or removal | ubiquitin-dependent protein catabolic process | organonitrogen compound catabolic process | regulation of cell communication | negative regulation of signal transduction | cell development | cellular protein metabolic process | anatomical structure morphogenesis | developmental process | spermatogenesis | cellular protein modification process | cellular metabolic process | regulation of cell death | modification-dependent protein catabolic process | chemotaxis | sexual reproduction | positive regulation of apoptotic signaling pathway | positive regulation of signaling | regulation of signaling | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | cytoplasmic vesicle | cell | cytoplasm | intracellular organelle | protein-containing complex | endomembrane system | plasma membrane | vesicle | beta-catenin destruction complex | endosome | membrane-bounded organelle | nucleus | organelle | cell periphery | early endosome | cytosol | intracellular vesicle | intracellular | membrane
