QuickView for SLCO1C1 (gene)

Gene Symbol:

SLCO1C1 Homo sapiens

Full name:

solute carrier organic anion transporter family member 1C1

Synonyms:

OATP-F, OATP1, OATP14, OATP1C1, OATPF, OATPRP5, SLC21A14, solute carrier organic anion transporter family member 1C1, OAT-RP-5, OATP-14, organic anion transporter F, organic anion transporter polypeptide-related protein 5, organic anion transporting polypeptide 14, solute carrier family 21 (organic anion transporter), member 14, solute carrier family 21 member 14, thyroxine transporter

Genomic Location:

Chr 12: 20739666-20797587

Description:

This gene encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the ge...

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This gene encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the gene encoding this protein may be associated with fatigue and depression in patients suffering from hyperthyroidism. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AGCYRWTTC_UNKNOWN ,  GNCF_01 ,  ARNT_01 ,  GATA_C ,  MYCMAX_03 ,  CACGTG_MYC_Q2 ,  ARNT_02 ,  CEBP_Q2 ,  TGCTGAY_UNKNOWN ,  TGCCAAR_NF1_Q6 ,  STAT5A_04 ,  WWTAAGGC_UNKNOWN ,  USF2_Q6

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Cytogenetic Map:

12p12.2

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